リオチロニンナトリウム

解説

リオチロニンナトリウム，リオチロニン(分解点236 ℃)のナトリウム塩．[α]_D＋18～＋22°(エタノール)．水に可溶．甲状腺腫，甲状腺機能低下症治療薬として使用される．チロキシンより速効性で2～5倍の効力がある．
森北出版「化学辞典（第2版）

製造

3,5-ジヨード-L-チロニンのヨウ素化で得られるリオチロニンナトリウム．

効能

甲状腺ホルモン補充薬

商品名

チロナミン (武田薬品工業)

化学的特性

white to beige powder

使用

One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

適応症

Liothyronine sodium (Cytomel) is the sodium salt of the naturally occurring levorotatory isomer of T3. Liothyronine is generally not used for maintenance thyroid hormone replacement therapy because of its short plasma half-life and duration of action. The use of T3alone is recommended only in special situations, such as in the initial therapy of myxedema and myxedema coma and the short-term suppression of TSH in patients undergoing surgery for thyroid cancer. The use of T3 alone may also be useful in patients with the rare condition of 5'-deiodinase deficiency who cannot convert T4 to T3.

定義

ChEBI: Liothyronine sodium is the sodium salt of liothyronine. Thought to be more active than levothyroxine and with a rapid (few hours) onset and short duration of action, liothyronine sodium is used in the treatment of hypothyroidism, particularly in cases of hypothyroid coma. It contains a 3,3',5-triiodo-L-thyroninate.

一般的な説明

3,3′,5′-Triiodo-L-thyronine (T₃) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T₄) serves as a precursor for T₃ and is generated in extrathyroidal tissues.