ファスジル

効能

血管拡張薬, Rho関連キナーゼ阻害薬

化学的特性

White Crystalline Solid

使用

Fasudil is a protein kinase A inhibitor and may be used in medicinal combinations for hepatitis treatment.

一般的な説明

A cell-permeable, reversible, and ATP-competitive Ca²⁺ antagonist with anti-vasospastic properties. Inhibits protein kinase A (K_i = 1.6 μM), protein kinase G (K_i = 1.6 μM), and myosin light chain kinase (K_i = 3.6 μM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC₅₀ = 10.7 μM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.

生物活性

Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.