ライムサイクリン

効能

抗生物質, タンパク質合成阻害薬

化学的特性

Yellow, hygroscopic powder.

使用

Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.

定義

ChEBI: A tetracycline-based broad-spectrum antibiotic. It is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by the "active transport" process across the intestinal wall.

応用例（製薬）

2-N-lysinomethyl-tetracycline. A water-soluble prodrug of tetracycline available for oral administration.
Its antimicrobial activity is due to the tetracycline content. It is lipophilic, rapidly absorbed from the gastrointestinal tract and widely distributed. Concentrations around 1 mg/kg have been found in maxillary sinus tissue some 3 h after administration of a conventional dose. The half-life is 7–14 h. Approximately 30% of an orally administered dose is excreted as active drug in the urine, where it achieves concentrations of 300 mg/L.
Its untoward effects and clinical uses are those of tetracycline, although it is claimed to be better tolerated.