Basic information Description Painkiller References Safety Related Supplier
Flupirtine maleate Structure

Flupirtine maleate

Chemical Properties

Melting point 186-188°C
storage temp.  Inert atmosphere,2-8°C
solubility  DMSO: soluble >20mg/mL
form  solid
color  white
λmax 343nm(CH3CN)(lit.)
Merck  14,4190
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey DPYIXBFZUMCMJM-BTJKTKAUSA-N
Flupirtine maleate is a selective neuronal potassium channel opener, oral easily absorbed, which has three efficacy about analgesic, muscle relaxant and neuroprotective. It showed analgesic effects to pain caused by a variety of reasons. Flupirtine maleate has no affinity to Ah receptor, which do not inhibit prostaglandin synthesis. It is not antagonistic naloxone. Pain intensity (ED50) was weaker than methadone, buprenorphine and morphine, about 50% of morphine. Comparable to that of pentazocine, Flupirtine maleate is better than pethidine, codeine, phenacetin and paracetamol. Such as in the hot plate test, the effect of the strength of flupirtine (ED50 of 32mg / Kg, oral administration) is about half of morphine, codeine is 2 times, 10 times stronger than paracetamol and phenacetin. In the wake of dog dental pulp stimulation experiment, the analgesic intensity (ED50 of 3.5mg/ Kg, oral administration) is same with pentazocine.

Safety Information

Safety Statements  22-24/25-35-20
WGK Germany  3
RTECS  EY8555800
HS Code  29333990

Usage And Synthesis

Preparation Products And Raw materials

Flupirtine maleate Supplier

Flupirtine maleate manufacturers