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外観
赤褐色の粉末
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溶解性
熱希塩酸に溶け、水又はエタノールにほとんど溶けない。
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用途
鉄強化剤研究用。
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効能
貧血治療薬, 造血薬, 鉄補充薬
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商品名
フェルム (日医工)
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説明
Ferrous fumarate is the ferrous salt form of fumarate. One of its most important applications is being used as iron supplements for the treatment of iron deficiency and anemia. It has been demonstrated that application of ferrous sulfate drops or a single daily dose of microencapsulated ferrous fumarate sprinkles plus ascorbic acid both result in successful treatment of anemia without remarkable side effects. However, recent studies have also shown that compared to other iron supplements, ferrous fumarate has a highest rate of inducing adverse reactions such as erosive mucosal injury in the gastrointestinal tract as well as nausea, vomiting and epigastric discomfort.
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化学的特性
Ferrous fumarate (iron(II)fumarate, C4H2Fe04) is an odorless, reddish-orange to reddish-brown powder. It may contain soft lumps that produce a yellow streak when crushed. It is prepared by admixing hot solutions of ferrous sulfate and sodium fumarate.
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使用
Ferrous fumarate is available as a syrup and may be useful in small children for the treatment and prophylaxis of iron deficiency. Iron(II) Fumarate is a a chemical used in the treatment of iron deficiency. More commonly used for this treatment is Ferrous Sulfate however Iron(II) Fumarate does maintain similar absorption profiles.
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定義
Ferrous fumarate is a dicarboxylic acid. Anhydrous salt of a combination of ferrous iron and fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains 33% iron by weight, does not melt at temperatures up to 280C, insoluble in alcohol, very slightly solubility. It is used in treatment of iron deficiency anemia.
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一般的な説明
Ferrous fumarate is a commonly used inexpensive substitute for other forms of iron, that is employed as a food iron fortificant.
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安全性プロファイル
Poison by
intraperitoneal route. Moderately toxic by
ingestion and subcutaneous routes. Human
systemic effects by ingestion: dyspnea,
nausea or vomiting, somnolence. When
heated to decomposition it emits acrid
smoke and irritating fumes. See also
FUMRIC ACID.
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参考文献
Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795.Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303.
