3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇
3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇
3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇 性质
| 沸点 | 431.5±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.196 |
| 储存条件 | Inert atmosphere,2-8°C |
| 溶解度 | H2O:50 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.08±0.40(Predicted) |
| 颜色 | 白色 |
3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇 用途与合成方法
|
5-HT 1E Receptor 1.1 nM (Ki) |
5-HT 1F Receptor 0.7 nM (Ki) |
5-HT 1A Receptor 63 nM (Ki) |
5-HT 1B Receptor 126 nM (Ki) |
5-HT 1D Receptor 63 nM (Ki) |
5-HT 2A Receptor 1259 nM (Ki) |
5-HT 2B Receptor 100 nM (Ki) |
5-HT 2C Receptor 316 nM (Ki) |
5-HT 6 Receptor >10,000 nM (Ki) |
5-HT 7 Receptor >10,000 nM (Ki) |
Despite its low affinity for other receptors [5-HT
1A
(63 nM), 5-HT
1B
(126 nM), 5-HT
1D
(63 nM), 5-HT
2A
(1259 nM), 5-HT
2B
(100 nM), 5-HT
2C
(316 nM), 5-HT
6
(>10,000 nM), 5-HT
7
(>10,000 nM), D
2
(501 nM), D
3
(631 nM), and α
1B
-adrenoceptors (1259 nM)], BRL54443 binds with high affinity at 5-HT
1F
receptors.
In DG membranes, BRL54443 selectively stimulates 5-HT
1E
receptors and potently inhibits forskolin-dependent cAMP production (IC
50
=14 nM). BRL 54443 also induces contraction (-log EC
50
=6.52).
Reduction of flinching was considered as antinociception. Ipsilateral, but not contralateral, peripheral administration of BRL54443 (5-HT(1E/1F); 3-300 microg/paw) significantly reduced formalin-induced flinching in rats.
3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-13221 | 5 mg | 505 | ||
| 2024-01-25 | HY-13221 | 3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇 | 57477-39-1 | 10mM * 1mLin DMSO | 555 |
