PRION PROTEIN (106-126) (HUMAN)
PRION PROTEIN (106-126) (HUMAN)
PRION PROTEIN (106-126) (HUMAN) 性质
| 沸点 | 2216.1±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.283±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 酸度系数(pKa) | 3.33±0.10(Predicted) |
| 形态 | 固体 |
| 水溶解性 | Soluble to 1 mg/ml in water |
PRION PROTEIN (106-126) (HUMAN) 用途与合成方法
PrP (106-126) (100 μM) induces mTOR phosphorylation over time in N2a cells. PrP (106-126)-treated cells show significantly increased ROS production in comparison with that of PBS-treated control cells. Knockdown of PRAS40 enhances PrP (106-126)-induced apoptosis. PRAS40 alleviates PrP (106-126)-induced neuronal apoptosis via mTOR-AKT activation. PrP (106-126) interacts selectively with porcine brain endothelial cells (PBEC) via their luminal side, and causes cumulative cell death, as shown by lactate dehydrogenase release, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction, Caspase 3 induction and direct cell counting. In addition, PrP (106-126), but not its corresponding scrambled peptide, produces a 50% reduction of the trans-endothelial electrical resistance, while the PBEC maintained confluency.
PRION PROTEIN (106-126) (HUMAN) 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-P0305 | PRION PROTEIN (106-126) (HUMAN) | 148439-49-0 | 1mg | 800 |
| 2024-04-30 | HY-P0305 | PRION PROTEIN (106-126) (HUMAN) | 148439-49-0 | 5mg | 2000 |
