テトラエチルアンモニウムブロミド

外観

白色～ほとんど白色粉末～結晶

解説

臭化テトラエチルアンモニウム，シュウカテトラエチルアンモニウム，C8H20BrN(210.16)．(C2H5)4N＋ Br－．略称TEAB．テトラエチルアンモニウムブロミドともいう．トリエチルアミンに臭化エチルを作用させると得られる第四級アンモニウム塩．潮解性結晶．分解点285 ℃．d₄²⁵"1.3880．水，アセトン，エタノール，クロロホルムに易溶，ベンゼンに難溶．pH 6.5(10％ 水溶液)．ガングリオン阻害剤，血圧降下作用があり，高血圧や末梢血管の診断治療に用いられる．

用途

臭化テトラエチルアンモニウム (tetraethylammonium bromide) は第四級アンモニウム塩である。テトラエチルアンモニウム（英語版）カチオンの供給源として利用される。

化学的特性

white to light yellow crystalline solid

使用

Tetraethylammonium Bromide, can be used as a source of tetraethylammonium ions for various pharmaceutical studies. It has also the ability to block K+ channels in various tissues.

一般的な説明

The use of ion-pairing reagents as mobile phase additives allows the separation of ionic and highly polar substances on reversed phase HPLC columns. The purity of mobile phase additives is of utmost importance to their successful application. Sigma-Aldrich offers an outstanding range of tailor-made reagents for anionic (quaternary ammonium and phosphonium salts) and cationic (alkanesulfonates) determination. All mobile phase additives are subject to rigorous testing with special emphasis on the requirements of modern reversed phase HPLC:

純化方法

Recrystallise the bromide from EtOH, CHCl3 or diethyl ether, or recrystallise it from acetonitrile and dry it over P2O5 under reduced pressure for several days. It also recrystallises from EtOH/diethyl ether (1:2), EtOAc, water or boiling MeOH/acetone (1:3) or by adding an equal volume of acetone and allowing to cool. Dry it at 100o in vacuo for 12 days, and store over P2O5. [Beilstein 4 IV 332.]