α-リノレン酸

外観

無色～褐色, 澄明の液体

定義

本品は、次の化学式で表される不飽和脂肪酸である。

溶解性

水に不溶。エタノール, エーテルに可溶。エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。

解説

α-リノレン酸，無色の液体．融点－11 ℃，沸点230～232 ℃(133 Pa)．d¹⁸₄ 0.914．n²⁰_D 1.4780．水に不溶，多くの有機溶剤に可溶．還元すればステアリン酸になる．ヒトや動物の組織には，Δ15-不飽和化酵素がないために生合成できず，食物から摂取しなければならない必須脂肪酸である．
森北出版「化学辞典（第2版）

化粧品の成分用途

ヘアコンディショニング剤、皮膚コンディショニング剤、洗浄剤、香料

製造

α-リノレン酸，3個のシス二重結合をもつ不飽和脂肪酸．グリセリドとして乾性油中に存在する．あまに油の混合脂肪酸から数次にわたる低温分別結晶法を繰り返して精製する．

使用上の注意

不活性ガス封入

化学的特性

clear light yellow to yellow liquid

天然物の起源

linolenic acid occurs as the glyceride in many seed fats. It is an essential fatty acid in the diet.

使用

linolenic acid is also known as alpha-linolenic acid; omega-3. An essential fatty acid found in most drying oils. It is slightly irritating to the mucous membranes. It may be used in a cosmetic preparation for any of the following broad uses: anti-static, cleansing, emollient, skin-conditioning, and surfactant properties.

定義

ChEBI: Alpha-linolenic acid is a linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect. It has a role as a micronutrient, a nutraceutical and a mouse metabolite. It is an omega-3 fatty acid and a linolenic acid. It is a conjugate acid of an alpha-linolenate and a (9Z,12Z,15Z)-octadeca-9,12,15-trienoate.

一般的な説明

Linolenic acid is a clear colorless liquid. (NTP, 1992)

空気と水の反応

Oxidizes in air to form peroxides, which spontaneously ignite. Insoluble in water. Sensitive to heat and moisture.

反応プロフィール

Linolenic acid is incompatible with bases, oxidizing agents and reducing agents. Also incompatible with peroxides, oxygen and water.

火災危険

Linolenic acid is probably combustible.

発がん性

Narisawa et al. found that diets high in perilla oil (with high a-linolenic acid but also high levels of linoleic acid) lowered the risk of colon cancer in a rat model initiated with the carcinogen N-methyl-Nnitrosourea. Okuno found a suppressive effect on diethylnitrosamine- induced heptaocarcinogenesis in male Fischer 344 rats treated with either safflower (high in linoleic acid) or perilla oil (high in both linoleic and α-linolenic acids). Kitano et al. found that 10% α-linolenic acid did not promote urninary bladder cancer initiated in rats with N-butyl-N-(4-hydrocybutyl)nitrosamine. Mice fed a-linolenic acid at 5–10% of the diet had increased mammary gland ductular cell proliferation.