-
外観
白色～ほとんど白色, 結晶性粉末～粉末
-
溶解性
エタノール又はアセトンに溶けやすく、メタノール又はエーテルにやや溶けやすく、水にほとんど溶けない。
-
用途
薬理作用研究用。
-
用途
マクロライド系抗生物質です。
細菌リボソーム 50s に結合し、タンパク質合
成阻害作用を示します。グラム陽性・陰性菌
に抗菌作用を示します。
-
用途
マクロライド系抗生物質です。
細菌リボソーム 50S に結合し、タンパク質
合成阻害作用を示します。グラム陽性・陰性
菌に抗菌作用を示します。
-
効能
抗生物質, タンパク質合成阻害薬
-
商品名
ルリッド (サノフィ)
-
使用上の注意
取扱う場合は、保護眼鏡、保護手袋及び保護マスクを用いて下さい。
-
説明
Roxithromycin, an oxime ether derivative of erythromycin, is a new macrolide antibiotic
of high potency and long duration. Its in v i m activity spectrum is similar to that of
erythromycin, but is superior to the latter against Legionella, Mycoplasma and Chlamydia.
-
化学的特性
White Solid
-
使用
Roxithromycin was one of the new generation erythromycins introduced in the 1980s. Improved acid stability was achieved by converting the 9-keto group to the more stable oxime and alkylation of the oxime to provide the methoxyethoxymethyl ether oxime. In vivo, roxithromycin exhibits higher tissue levels and a longer half-life while being slightly less potent than erythromycin in vitro.
-
抗菌性
Activity against common pathogens is comparable to that of erythromycin. It is active against L. monocytogenes, C. jejuni, H. ducreyi, G. vaginalis, Bord. pertussis, C. diphtheriae, B. burgdorferi, H. pylori, the M. avium complex, Chlamydia spp., and U. urealyticum.
-
応用例（製薬）
A semisynthetic derivative of erythromycin A formulated for oral use.
-
副作用
It is generally well tolerated, adverse effects being described in 3–4% of patients, mostly gastrointestinal disturbance (abdominal pain, nausea and diarrhea). Headache, weakness, dizziness, rash and reversible changes in liver function tests and increased eosinophils and platelets have also been described.
