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外観
白色～ほとんど白色粉末～結晶
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解説
(3β)-3-hydroxypregn-5-en-20-one．C21H32O2(316.48)．プレグネノロンは，コレステロール，ジオスゲニン，スチグマステロールなどから合成される．無色の針状結晶．融点190 ℃．[α]D＋28°(エタノール)．クロロホルムに可溶，エタノールに微溶，ベンゼン，石油エーテルに難溶．副じん皮質ホルモン，プロゲステロンなどの合成で重要な中間体である．森北出版「化学辞典（第2版）
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用途
プレグネノロン (pregnenolone) は、プロゲステロン、コルチコイド、アンドロゲン、およびエストロゲンのステロイド生成にかかわるプロホルモンである。
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用途
プレグネノロンは体内であらゆるホルモンに変換されるプロホルモンである。
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効能
ホルモン前駆体
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説明
Pregnenolone serves as the common precursor in the formation of the adrenocorticoids and other steroid
hormones. This C21 steroid is converted via enzymatic oxidations and isomerization of the double bond to a
number of physiologically active C21 steroids, including the female sex hormone progesterone and the
adrenocorticoids hydrocortisone (cortisol), corticosterone, and aldosterone. Oxidative cleavage of the
two-carbon side chain of pregnenolone and subsequent enzymatic oxidations and isomerization lead to C19
steroids, including the androgens testosterone and dihydrotestosterone. The final group of steroids, the C18
female sex hormones, are derived from oxidative aromatization of the A ring of androgens to produce estrogens.
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化学的特性
white to off-white powder
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使用
Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an
tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A
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定義
ChEBI: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
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一般的な説明
Pregnenolone is an endogenous steroid hormone involved in the biological synthesis of other hormones. Pregnenolone is monitored as an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations where diagnosis of 21-hydroxylase and 11-hydroxylase deficiency has been ruled out. This Certified Spiking Solution? is suitable for use in LC-MS/MS testing methods as a starting material in the preparation of calibrators, controls and linearity standards.
