チモキノン

外観

うすい黄色～褐色粉末～結晶

解説

2-isopropyl-5-methyl-1,4-benzoquinone．C10H12O2(164.2)．

チモキノンは，シソ科，その他の精油に含まれる．黄色の結晶．融点45.5 ℃，沸点232 ℃．冷エタノール，エーテルに易溶，クロロホルム，ベンゼン，ヘキサンに可溶，水に難溶．森北出版「化学辞典（第2版）

説明

Thymoquinone is an allergen In different cedar species.

化学的特性

orange to brown crystals

使用

Thymoquinone is a phytochemical compound found in the plant Nigella sativa. Thymoquinone has antioxidant effects and has been shown to protect against heart, liver and kidney damage in animal studies, as well as having possible anti-cancer effects. Thymoquinone also has analgesic and anticonvulsant effects in animal models. Thymoquinone is an angiogenesis inhibitor.

接触アレルゲン

Thymoquinone is an allergen in different cedar species, Cupressaceae family, such as incense cedar (Calocedrus decurrens Florin) used for pencils, chests or toys, and western cedar (Thuja plicata Donn.) as used for hard real- izations such as construction or boats.

抗がん研究

Thymoquinone acts on cell cycleand inhibits progression from G1 toS phase by targeting the cellcycle-related proteins such as cyclinD1, cyclin E and p27.It also exhibits histone deacetylase(HDAC) inhibitory effects andtargets p21 and Maspin.Induces pro-apoptotic gene, Bax,and downregulates anti-apoptoticgene Bcl-2
Barkat et al.(2017)