アジピン酸ジメチル

外観

無色～わずかにうすい黄色, 澄明の液体

定義

本品は、アジピン酸(*)とメチルアルコールのジエステルであり、次の化学式で表される。
参照表示名称：アジピン酸

溶解性

水に難溶, エタノール, エーテル, 多くの有機溶媒に易溶。

用途

有機合成原料。

化粧品の成分用途

エモリエント剤、可塑剤、溶剤

説明

Dimethyl adipate (DMA) is a colourless and flammable liquid. It is soluble in alcohol and ether but sparingly soluble in water. DMA is incompatible with strong oxidising agents, and on decomposition, it emits carbon monoxide, irritating and toxic fumes and gases, and carbon dioxide. DMA reacts with acids, alkalis, and strong oxidants. DMA is synthesised by the esterification of adipic acid. DMA is part of a dibasic ester (DBE) blend used as a major ingredient in several paint strippers, and the DBE blends used in paint stripping formulations contain a major portion (about 90%) of DMA. DMA is used as a chemical intermediate (polymers, agrochemicals), cellulose resins, a speciality solvent (inks, coatings, adhesives), and an emollient and can also be utilised as a paint remover and plasticiser.

化学的特性

Dimethyl adipate is a colorless liquid. It is a fatty acid methyl ester.

使用

Dimethyl adipate is used in cosmetics (in emollients and skin conditioning).It is used as a plasticizer for cellulose-type resins and a finish remover.It is also used in agrochemicals and dye as well as a precursor for the preparation of active pharmaceutical ingredients. Further, it serves as a polymer intermediate. In addition to this, it is employed as a solvent for paint stripping and resins.

調製方法

Dimethyl adipate is manufactured via esterification of adipic acid and methanol in the presence of an acid catalyst.

一般的な説明

Colorless liquid.

空気と水の反応

Flammable. Hydrolyzed by strong mineral acids and strong alkalis.

反応プロフィール

Dimethyl adipate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

健康ハザード

Exposures to dimethyl adipate cause toxicity and adverse health effects in laboratory animals and humans. Workplace exposures to dimethyl adipate by inhalation, ingestion, or skin absorption cause harmful and irritation effects to users.

安全性プロファイル

Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

発がん性

In a chronic inhalation toxicity study of dimethyl adipate, groups of male and female rats were exposed to 400 mg/m³ of dimethyl adipate over a 90-day period. Focal respiratory metaplasia of the olfactory epithelium was found. These nonneoplastic lesions were minimal to mild in severity .

予防処置

During handling of dimethyl adipate, occupational workers should be careful and use self-contained breathing apparatus, rubber boots, and heavy rubber gloves and avoid prolonged period of exposures. Workers should avoid contact of dimethyl adipate with skin, eyes and nose.