ウノプロストン イソプロピルエステル

効能

抗緑内障薬

商品名

レスキュラ (日東メディック)

説明

Unoprostone isopropyl ester, a novel prostaglandin derivative, was launched in Japan as eye drops for the treatment of glaucoma and ocular hypertension. In animal and human studies, a single drop of unoprostone isopropyl ester induced significant decrease in intraocular pressure without systemic effects, myosis or mydriasis. Unlike prostaglandin analogs such as PGF_2α, unoprostone isopropyl ester does not cause irritation in outer segment of the eye or significant changes in aqueous protein concentration and corneal endothelial permeability. Unoprostone isopropyl ester is suggested to act by increasing uveoscleral outflow or by decreasing episcleral venous pressure, resulting in ocular hypotension.

化学的特性

Clear Colourless Oil

使用

Isopropyl unoprostone is an antiglaucoma,it is used in treatment of ocular hypertension.

定義

ChEBI: A carboxylic ester that is the isopropyl ester of unoprostone.

危険性

A poison.