BDP5290
BDP5290 性质
| 沸点 | 584.0±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.56±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：12.5 mg/mL（33.62 mM） |
| 酸度系数(pKa) | 10.83±0.50(Predicted) |
BDP5290 用途与合成方法
|
ROCK1 5 nM (IC 50 ) |
ROCK2 50 nM (IC 50 ) |
MRCKα 10 nM (IC 50 ) |
MRCKβ 100 nM (IC 50 ) |
The K i of BDP5290 for MRCKα is 10 nM, which is slightly more than the K i of 4 nM for MRCKβ. 3 μM BDP5290 completely inhibits myosin II light chain (MLC) phosphorylation induced by MRCKβ, but not by ROCK1 or ROCK2. At higher concentrations, BDP5290 reduces MLC phosphorylation (pMLC) to undetectable levels. BDP5290 reduces MDA-MB-231 invasion at all tested concentrations starting from 0.1 μM, with virtually complete inhibition at 10 μM. After 24 hours in the presence of BDP5290 cell viability is slightly reduced with an EC 50 >10 μM. Wound closure is inhibited by >60% at 1 μM BDP5290, a concentration that has no effect on cell viability.
BDP5290 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-12437 | 1 mg | 681 | ||
| 2024-01-25 | HY-12437 | BDP5290 | 1817698-21-7 | 5mg | 1500 |
