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外観
凍結乾燥品
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溶解性
水に溶ける。
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効能
診断薬 (副腎皮質機能), メラノコルチン受容体作動薬
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説明
Cosyntropin (Tetracosactide acetate) is a synthetic polypeptide that consists of amino acid residues 1 through 24 of
human ACTH, but that has the full biological activity of its parent. Because it is of synthetic
origin, it is less allergenic than ACTH of natural origin. Cosyntropin is used as a diagnostic
agent in the screening of patients suspected of having adrenocortical insufficiency. Normally,
parenteral administration of cosyntropin acts rapidly on the adrenal cortex to effect release of
plasma hydrocortisone; when performing the test, the hydrocortisone levels are compared to a
control blood sample taken earlier.
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化学的特性
White or yellow, amorphous powder.
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定義
ChEBI: A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone (corticotropin). A segment similar in all species, it contains the biological activity that stimulates production of cort
costeroids in the adrenal cortex. It is used diagnostically to investigate adrenocortical insufficiency.
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適応症
Cosyntropin (Cortrosyn) is a polypeptide that consists
solely of the first 24 amino acids of corticotropin. It appears
to offer an advantage over the naturally occurring
hormone in that it has a longer duration of action and
lacks the antigenic portion of corticotropin. Although
the short cosyntropin test is recognized as a valid
screening test to assess adrenocortical insufficiency, the
overnight metyrapone test or insulin hypoglycemia test
may prove more sensitive.
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一般的な説明
Cosyntropin (Cortrosyn) is a syntheticpeptide containing the first 24 amino acids of natural corticotropin.Cosyntropin is used as a diagnostic agent to testfor adrenal cortical deficiency. Plasma hydrocortisone concentrationis determined before and 30 minutes after theadministration of 250 g of cosyntropin. Most normal responses result in an approximate doubling of the basalhydrocortisone concentration in 30 to 60 minutes. If the responseis not normal, adrenal insufficiency is indicated.Such adrenal insufficiency could be a result of either adrenalor pituitary malfunction, and further testing is requiredto distinguish between the two. Cosyntropin (250 μg infusedwithin 4–8 hours) or corticotropin (80–120 U/day for3–4 days) is administered. Patients with functional adrenaltissue should respond to this dosage. Patients who respondaccordingly are suspected of hypopituitarism, and the diagnosiscan be confirmed by other tests for pituitary function.Patients who have Addison disease, however, show little orno response.
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副作用
Common side effects of Tetracosactide acetate may include:
an allergic reaction (hives; difficult breathing; swelling of your face, lips, tongue, or throat);
fast or slow heartbeats;
increased blood pressure;
rash;
swelling in your hands or feet.
