スペクチノマイシン二塩酸塩五水和物

外観

白色～黄色, 結晶～粉末

溶解性

水に溶け、エタノールには加温後溶け、アセトンに溶けない。水に溶けやすく、メタノールに溶けにくく、エタノール、クロロホルムにほとんど溶けない。

用途

アミノグリコシド系抗生物質 です。細菌リボソーム 30S に結合し、タン パク質合成を阻害します。淋菌に優れた抗菌 作用を示します。

効能

抗生物質, タンパク質合成阻害薬

商品名

トロビシン (ファイザー)

説明

Spectinomycin was found in the culture broth of Streptomyces spectabilis by Upjohn Co. in 1961. This antibiotic was intended for use in treating various infections, as are the other aminoglycoside antibiotics, but its activity is insufficient for clinical efficacy except against gonorrhea. Spectinomycin does not develop crossresistance with any other antibiotic and shows low toxicity; it is used by deep intramuscular injection for “single-session,” bolusinjection therapy of gonorrhea.

化学的特性

White or almost white, slightly hygroscopic powder.

使用

Spectinomycin Dihydrochloride Pentahydrate is a new animal drug application (ANADA) administered in the drinking water of chickens as an aid in the control of airsacculitis; Also, it is an aminocylcitol antibiotic.

定義

ChEBI: A hydrate that is the pentahydrate form of spectinomycin hydrochloride. An antibiotic that is active against gram-negative bacteria and used to treat gonorrhea.

一般的な説明

A broad spectrum aminoglycoside antibiotic that contains two glucose moieties. Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure. A resistance gene (aph) which encodes a spectinomycin has been cloned from Legionella pneumophila (disease agent for Legionnaire’s disease) kinase and expressed in E. coli. Potency: ≥500 μg/mg.