Sulfamethizole-d
4 is intended for use as an internal standard for the quantification of sulfamethizole by GC- or LC-MS. Sulfamethizole is a broad-spectrum sulfonamide antibiotic (MIC
90s = 1.25-5,000 μg/ml against clinical isolates of
E. coli and
K. pneumoniae).
1 It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.
