SM16 性质
| 沸点 | 691.3±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.354±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO:65.0(最大浓度 mg/mL);150.99(最大浓度 mM) |
| 形态 | 固体 |
| 酸度系数(pKa) | 11.23±0.10(Predicted) |
SM16 用途与合成方法
Ki: ALK5 (10 nM), ALK4 (1.5 nM)
SM 16 inhibits TGFβ-induced plasminogen activator inhibitor-luciferase activity (IC 50 =64 nM) and TGFβ- or activin-induced Smad2 phosphorylation at concentrations between 100 and 620 nM. SM 16 is tested against >60 related and unrelated kinases and shows moderate off-target activity only against Raf (IC 50 =1 μM) and p38/SAPKa (IC 50 =0.8 μM). SM 16 exhibits no inhibitory activity against ALK family members ALK1 and ALK6.
SM 16 penetrates tumor cells in vivo , suppressing tumor phosphorylated Smad2/3 levels for at least 3 h following treatment of tumor-bearing mice with a single i.p. bolus of 20 mg/kg SM 16. The growth of established AB12 tumors is significantly inhibited by 5 mg/kg/d SM 16 (P<0.001) delivered via s.c. miniosmotic pumps over 28 days.
SM16 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-111482 | 1 mg | 500 | ||
| 2024-01-25 | HY-111482 | SM16 | 614749-78-9 | 5mg | 1100 |
