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外観
黄色、結晶性粉末～粉末
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溶解性
水0.3mg/kg、クロロホルム204、トルエン73、キシレン50、アセトン29、エタノール2.1、ヘプタン1.8（g/ ㎏）(和光純薬時報 Vol.83, No.3(2015), p22)アセトンに溶け、水及びエタノールにほとんど溶けない。
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効能
抗凝固薬, ビタミンK拮抗薬
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説明
Diphacinone is also called 2-(diphenylacetyl)indan-1,3-dione,
is a yellow powder
which is practically insoluble in water, readily soluble
in chloroform, toluene, xylene, acetone, ethanol, heptane,
alkalis [9, p. 431].
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使用
Diphacinone is an anticoagulant rodenticide widely used to control rodent infestations.
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調製方法
Diphacinone is produced by condensation of 1,1-diphenyl
acetone with dimethyl phthalate in the presence of sodium
methoxide (30).
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一般的な説明
Odorless pale yellow crystals. Used as a rodenticide and anticoagulant medication.
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空気と水の反応
Practically insoluble in water (17mg/L). Hydrolyzed by strong acid.
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反応プロフィール
DIPHACINONE is a ketone, and behaves as a weak acid. Forms water soluble alkali metal salts. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
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健康ハザード
DIPHACINONE is extremely toxic; probable oral lethal dose in humans is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150-lb. person. Many medical conditions will be aggravated by DIPHACINONE.
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火災危険
When heated to decomposition DIPHACINONE emits acrid smoke and fumes. Sensitive to light.
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农业用途
Rodenticide: A U.S. EPA restricted Use Pesticide (RUP) when
the formulation contains 3% or more of diphacinone.
Diphacinone is an anti-coagulant rodenticide bait used for
control of rats, mice, voles and other rodents. It is available
in meal, pellet, wax block, and liquid bait formulations, as
well as in tracking powder and concentrate formulations.
It is used in general agriculture and in food-processing areas. The top five uses for diphacinone in California are on
landscapes, general vertebrate pest control, around structures and right of ways, and on oranges. This material is
also used as an anticoagulant medication. Not approved for
use in EU countries.
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製品名
DE-PESTER®[C]; DIDANDIN®;
DIPAXIN®; DITRAC®; GOLD CREST®; KILL-RO
RAT KILLER®; LIQUA-TOX®, diphacinone sodium
salt; ORAGULANT®; P. C. Q. ®; PID®; PROMAR®;
RAMIK®; RAT KILLER®; RODENT CAKE®[C];
SOLVAN®; TOMCAT®; U 1363®
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安全性プロファイル
Poison by ingestion.
Inlxbits blood clotting, leading to
hemorrhages. Action similar to coumadin
(warfarin). A pesticide used in rodent
control. When heated to decomposition it
emits acrid smoke and irritating fumes
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代謝経路
Diphacinone is a member of the indandione class of anti-coagulants.
Its fate in rats and mice has been reported but no information on its
degradation in soil or plants has been published. It is metabolised by
hydroxylation and conjugation.
