Conivaptan hydrochloride

• Product Name:Conivaptan hydrochloride
• Synonyms: (1,1'-Biphenyl)-2-carboxamide, N-(4-((4,5-dihydro-2-methylimidazo(4,5-D)(1)benzazepin-6(1H)-yl)carbonyl)phenyl)-, monohydrochloride Conivaptan HCl Conivaptan hydrochloride [usan] Unii-75L57R6X36 Vaprisol Conivaptan hydrochkoride N-[4-[(4,5-Dihydro-2-MethyliMidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-[1,1'-Biphenyl]-2-carboxaMide Hydrochloride Conivaptan HCI
• CAS:168626-94-6
• MF:C32H26N4O2.HCl
• MW:535.04
• EINECS:1312995-182-4
• Mol File:168626-94-6.mol
• 

Arginine vasopressin is intimately involved in volume homeostasis, and elevated levels of arginine vasopressin are responsible for the pathogenesis and progression of diseases with an imbalance of sodium and water, particularly congestive heart failure. To restore homeostasis, antagonism of vasopressin receptors is a practical solution. As such, conivaptan has been developed and launched as a dual V1a and V2 vasopressin receptor antagonist. As a competitive, reversible inhibitor of both subtypes, conivaptan can modulate systemic vascular resistance through the V1a receptor (Ki ? 0.48 nM) distributed in vascular smooth muscle cells, cardiomyocytes, hepatocytes, and platelets and blocks the renal V2 receptor (Ki ? 3.04 nM) resulting in enhanced diuresis, thereby increasing serum sodium concentration and reducing total body volume. Currently, the drug is approved for the management of refractory hyponatremia and potentially lifethreatening sodium and water imbalance, but it has shown promise as a potential treatment option for other diseases, such as congestive heart failure, syndrome of antidiuretic hormone, diabetes insipidus, and liver cirrhosis.

• Conivaptan HCl
• 
• US $0.00 /g
• CAS:168626-94-6
• Min. Order: 1g
• Purity: 98% HPLC
• Supply Ability: 100kg
• 2024-03-12

• Conivaptan hydrochloride
• 
• US $0.00-0.00/kg
• CAS:168626-94-6
• Min. Order: 1kg
• Purity: 98%
• Supply Ability: 1Ton
• 2022-09-30

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Conivaptan Hydrochloride
  CAS:168626-94-6
  Package:250Mg,25Mg More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Adamas Reagent, Ltd.
• Tel:400-6009262 16621234537
• Products Intro:Product Name:Conivaptan hydrochloride
  CAS:168626-94-6
  Purity:对照品 Package:10mg~500mg Remarks:AC00058200A
• CB Index:59
• Related Information:Catalog(14113)

• Company Name:Shanghai Longsheng chemical Co.,Ltd.
• Tel:021-58099652-8005 13585536065
• Products Intro:Product Name:Conivaptan hydrochloride
  CAS:168626-94-6
  Purity:99% More...
• CB Index:59
• Related Information:Catalog(9816)

• Company Name:XiaoGan ShenYuan ChemPharm co,ltd
• Tel: 15527768850
• Products Intro:CAS:168626-94-6
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• CB Index:52
• Related Information:Catalog(8849)

• Company Name:Tongchuang Pharma(Suzhou). Co., Ltd.
• Tel:0512-63263366 18912765016
• Products Intro:CAS:168626-94-6
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• CB Index:62
• Related Information:Catalog(1002)

• Company Name:Beijing Comparison Pharmaceutical Technology Co., Ltd
• Tel:010-52878169 15701683040
• Products Intro:Product Name:N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide hydrochloride
  CAS:168626-94-6
  Purity:100% Package:10g/;1g/ More...
• CB Index:58
• Related Information:Catalog(4713)