Nafcillin sodium is a narrow-spectrum β-lactam antibiotic. It is used to treat infections caused by Gram-positive bacteria, in particular, species ofStaphylococcithat are resistant to other penicillins. It has been used to study penicillin-binding proteins (PBPs), such as 2a, and heterogeneous expression of methicillin resistance inStaphylococcus aureus. It is a potential therapy of meningitis due toStaphylococcus aureus.
