2-クロロトルエン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H226：引火性の液体および蒸気

  H332：吸入すると有害

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P273：環境への放出を避けること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

2-クロロトルエン 価格

MSDS Information

• 1-Chloro-2-methylbenzene

2-クロロトルエン 化学特性,用途語,生産方法

• 外観

  無色澄明の液体

• 溶解性

  水に不溶 (0.037g/100g, 25℃), アルコール, エーテル等各種有機溶剤と混和。エタノール、ベンゼン、クロロホルムに溶け、水にほとんど溶けない。

• 用途

  塗料?農薬?医薬中間体、中沸点溶剤

• 用途

  有機合成原料、溶剤。

• 説明

  2-Chlorotoluene can be mineralized completely by Rhodococcus, strain OCT 10 DSM 45596(T). It is used in the preparation of 3-chloro-4-methylcatechol and 4-chloro-3-methylcatechol. The oxidation of 2-chlorotoluene is very well catalyzed by the enzymes: toluene dioxygenase of P. putida F1 and chlorobenzene dioxygenase from Burkholderia, strain PS12.

• 化学的特性

  o-Chlorotoluene is a flammable, colorless liquid with an aromatic odor.

• 使用

  Solvent and intermediate for organic chemicals and dyes.
  2-Chlorotoluene is used for permanganate oxidation to give o-chlorobenzoic acid. It is used in the preparation of 3-chloro-4-methylcatechol and 4-chloro-3-methylcatechol.
  2-Chlorotoluene can be used as a precursor to synthesize aryl coupling products via palladium-catalyzed Negishi cross-coupling. It can also be used in the Buchwald-Hartwig amination to synthesize arylamines.

• 製造方法

  The solution of cuprous chloride is cooled in an ice bath 0-5° C temperature. In this cold solution, the 2-methylbenzenediazonium is poured with constant shaking and allowing the mixture to come to room temperature. After about 10 minutes, the mixture gradually warmed with a good shaking.As the temperature rises the brown addition product begins to decompose with the evolution of nitrogen and with the formation of an oily layer of 2-chlorotoluene. When the decomposition reaction is at an end, the mixture is steam distilled, continuing the process only as long as oily droplets are present in the distillate, for the product is not appreciably soluble in water. The layer of 2-chlorotoluene is carefully separated and washed twice with an equal volume of concentrated sulfuric acid, which removes both the 2-cresol and the azo compound. Then 2-chlorotoluene is washed with water in order to remove the inorganic acid. Finally, 2-chlorotoluene is dried over calcium chloride, distilled, using an air condenser and collecting the product boiling at 153-158° C. Pure 2-chlorotoluene boils at 157° C. The yield is 25-30 g.
  
  Experiments in Organic Chemistry, L. F. Fieser, 216, 1941
  Highly Selective Oxidative Monochlorination To Synthesize Organic Intermediates: 2-Chlorotoluene, 2-Chloroaniline, 2-Chlorophenol, and 2-Chloro-4-methylphenol

• 一般的な説明

  Colorless liquid with an aromatic odor. Denser than water and poorly soluble in water. Hence sinks in water .

• 空気と水の反応

  Slightly water soluble.

• 反応プロフィール

  2-Chlorotoluene may be incompatible with strong oxidizing and reducing agents. Also may be incompatible with amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Reacts violently with dimethyl sulfoxide .

• 危険性

  Toxic by inhalation. Eye, skin, and upper respiratory tract irritant.

• 健康ハザード

  Inhalation of vapor may cause respiratory irrtation. Prolonged and repeated vapor exposures may produce systemic toxic effects.

• 安全性プロファイル

  Moderately toxic by unspecified routes. Flammable when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also TOLE CHLORIDE and CHLORINATED HYDROCARBONS, AROMATIC.

• 職業ばく露

  o-Chlorotoluene is widely used as a solvent and intermediate in the synthesis of dyes, synthetic rubber; pharmaceuticals; and other organic chemicals. Used as an insecticide, bactericide.

• 輸送方法

  UN2238 Chlorotoluenes, Hazard Class: 3; Labels: 3-Flammable liquid.

• 純化方法

  Dry 2-chlorotoluene for several days with CaCl2, then distil it from Na using a glass helices-packed column. [Beilstein 5 IV 805.]

• 不和合性

  Incompatible with acids, alkalis, oxidizers, reducing materials; water

• 廃棄物の処理

  In accordance with 40CFR165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

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