WIN 55,212-2メシル酸塩

WIN 55,212-2メシル酸塩 価格

WIN 55,212-2メシル酸塩 化学特性,用途語,生産方法

• 外観

  白色〜黄褐色, 結晶〜粉末

• 溶解性

  N,N-ジメチルホルムアミド溶状：試験適合

• 説明

  (+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with K_i values of 62.3 and 3.3 nM for human recombinant CB₁ and CB₂ receptors, respectively. In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. This effect is fully counteracted by rimonabant at a concentration of 10 nM, by decreasing Ca²⁺ concentrations below 0.2 mM, or by the IP₃ receptor antagonist xestospongin C at a concentration of 1 μM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC₅₀ value of 26 μM.

• 使用

  (R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/? mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

• 一般的な説明

  WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

• 生物活性

  Nanomolar affinity cannabinoid receptor agonist (K i values are 62.3 and 3.3 nM at the human cloned CB 1 and CB 2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™ .

WIN 55,212-2メシル酸塩 生産企業

Global(153)Suppliers

131543-23-2, WIN 55,212-2メシル酸塩 キーワード