フィルグラスチム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H361：生殖能または胎児への悪影響のおそれの疑い

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P281：指定された個人用保護具を使用すること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

フィルグラスチム 価格

フィルグラスチム 化学特性,用途語,生産方法

• 外観

  無色澄明の液体

• 説明

  Filgrastim is a recombinant human granulocyte colony stimulating factor (G-CSF) indicated as an adjunct to cancer chemotherapy for patients with non-myeloid malignancies. It reduces the duration of chemotherapy-induced neutropenia by forcing immature leucocytes to differentiate into neutrophils, thereby decreasing the incidence and length of infections.Bone pain is the most significant side effect.Chugai launched the second G-CSF, lenograstim, in December 1991. Other potential uses include bone marrow transplants, myelodysplastic syndromes and febrilelchronic neutropenia.

• 化学的特性

  Clear, colourless or slightly yellowish liquid

• 使用

  Filgrastim is a human granulocyte colony stimulating factor (G-CSF) used to treat neutropenia.

• 適応症

  Filgrastim (Neupogen) is a human recombinant granulocyte colony–stimulating factor (rG-CSF) produced using recombinant DNA technology. It acts on precursor hematopoietic cells in the bone marrow by binding to specific receptors that stimulate cellular proliferation and differentiation into neutrophils. It also enhances some neutrophil functions, including phagocytosis and antibody-dependent killing.

• 臨床応用

  Filgrastim, G-CSF, Neupogen, stimulates the proliferation ofgranulocytes (especially neutrophils) by mobilizinghematopoietic stem cells in the bone marrow. The native protein is glycosylated.Filgrastim selectively stimulates proliferation and differentiationof neutrophil precursors in the bone marrow. Thisleads to the release of mature neutrophils into the circulationfrom the bone marrow. Filgrastim also affects mature neutrophilsby enhancing phagocytic activity, priming the cellularmetabolic pathways associated with the respiratoryburst, enhancing antibody-dependent killing, and increasingthe expression of some functions associated with cell surfaceantigens.
  In patients receiving chemotherapy with drugs such ascyclophosphamide, doxorubicin, and etoposide, the incidenceof neutropenia accompanied by fever is rather high.Administration of G-CSF reduces the time of neutrophilrecovery and duration of fever in adults with acute myelogenousleukemia. The number of infections, days thatantibiotics are required, and duration of hospitalization arealso reduced.

• 副作用

  The drug is generally well tolerated, with the major adverse reaction being mild to moderate bone pain secondary to stimulation of bone marrow proliferation.

フィルグラスチム 生産企業

Global(42)Suppliers

121181-53-1, フィルグラスチム キーワード