エスクレントシドA

化学名:エスクレントシドA

CAS番号.65497-07-6

英語名:Esculentoside A

CBNumberCB3983421

MFC42H66O16

MW826.96

MOL File65497-07-6.mol

别名

エスクレントシドA

(2S,4aR,6aS,6bR,8aR,9R,10R,11S,12aR,12bR,14bS)-10-{[(2S,3R,4R,5R)-3,4-ジヒドロキシ-5-{[(2S,3R,4S,5S,6R)-3,4,5-トリヒドロキシ-6-(ヒドロキシメチル)オキサン-2-イル]オキシ}オキサン-2-イル]オキシ}-11-ヒドロキシ-9-(ヒドロキシメチル)-2-(メトキシカルボニル)-2,6a,6b,9,12a-ペンタメチル-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-イコサヒドロピセン-4a-カルボン酸

2β,23-ジヒドロキシ-3β-(4-O-β-D-グルコピラノシル-β-D-キシロピラノシルオキシ)オレアナ-12-エン-28,30-二酸30-メチル

エスクレントシドA物理性質

融点	>192°C (dec.)
沸点	936.7±65.0 °C(Predicted)
比重(密度)	1.42±0.1 g/cm3(Predicted)
貯蔵温度	Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解性	DMSO（微量）、メタノール（微量）
酸解離定数(Pka)	4.39±0.70(Predicted)
外見	個体
色	ペールイエロー
安定性：	吸湿性

安全性情報

Sフレーズ	24/25
HSコード	29389090

危険有害性情報のコード(GHS)

エスクレントシドA 価格

製品番号	包装	価格	製品説明	購入
関東化学株式会社(KANTO) 49063-04	10mg	￥104000	エスクレントシドＡ	購入

エスクレントシドA 化学特性,用途語,生産方法

使用
Esculentoside A is a saponin isolated from the root of Phytolacca esculenta. Modulates the immune response. and effects cell proliferation and apoptosis in cells. Anti-inflammatory. 500
薬物動態学
Esculentoside A is a triterpenoid saponin isolated from the root of Phytolacca esculenta. Studies have revealed that this triterpenoid exhibits a strong anti-inflammatory property. Ci et al. (2015) observed the anti-inflammatory potency of esculentoside A against allergic airway inflammation in a mouse model. They found that the drug enhanced nuclear Nrf-2 translocation in the lungs of ovalbumin-challenged mice and also decreased airway inflammation (Ci et al., 2015). Esculentoside A enhanced the intracellular anti-oxidant potentials, reduced Th2 cytokine level and down-regulated the expression of adhesion molecule mRNA in lung tissues. Zhang et al. (2014) found that esculentoside A could rectify carbon tetrachlorideinduced acute liver injury in mice. The drug successfully cured the histopathological damage induced by carbon tetrachloride. Rectification has been also noted through the down-regulation of inflammatory molecules and oxidative stresses associated with PPAR-γ, NF-κB and ERK signal pathways (Zhang et al., 2014). Ma et al. (2013) analyzed the role of esculentoside A on lupus nephritis-induced BXSB mice (where male SB/Le mice and female C57BL/6 mice were hybridized, creating a recombinant inbred species). They observed that esculentoside A application significantly reduced urine protein excretion and improved renal function by promoting apoptosis of glomerular intrinsic cells and renal tubular epithelial cells (Ma et al., 2013). The efficacy was also aided by the down-regulation of inflammatory cytokines.
Wang et al. (2016) elucidated the role of esculentoside A against acetaminophen-induced liver toxicity in mice and observed that Nrf2-regulated the survival mechanism via the AMPK/ Akt/GSK3β pathway.

エスクレントシドA 生産企業

65497-07-6, エスクレントシドA キーワード

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