アバスチン

アバスチン 化学特性,用途語,生産方法

• 解説

  アバスチンは，結腸癌(けっちょうがん)・直腸癌(ちょくちょうがん)の治療薬「ベバシズマブ」の商品名。

  小学館 デジタル大辞泉について　情報 | 凡例
  

• Originator

  Genentech (US)

• brand name

  Avastin

• 酵素阻害剤

  This humanized monoclonal antibody (MW = 149.2 kDa; CAS 216974-75- 3), known by the tradename Avastinò, is an angiogenesis inhibitor that targets vascular endothelial growth factor A (VEGF-A). Because VEGF is the key angiogenic factor in tumors, blocking VEGF signal transduction can lead to tumor growth arrest and inhibition of metastasis. The rationale for Avastin therapy is premised on findings that high VEGF expression correlates with (a) reduced overall survival, (b) disease progression, (c) greater risk of relapse, (d) lymph node involvement, and (e) malignant pleural effusion. By binding directly bind to VEGF-A, Avastin blocks its interaction with endothelial cell VEGF receptors, thereby inhibiting neovascularization and depriving cancer cells of vital nutrients and oxygen. Avastin is approved for: metastatic colorectal cancer (mCRC), when started with the first or second intravenous 5-FU–based chemotherapy for metastatic cancer; advanced-stage nonsquamous, non–small cell lung cancer (NSCLC), when administered in combination with carboplatin and paclitaxel in patients who have not received chemotherapy for their advanced disease; metastatic renal cell cancer (mRCC) when used with interferon-a; and glioblastoma multiforme (GBM) in adult patients whose cancer has progressed after prior treatment.

• target

  Angiogenesis is important for tumour growth and metastasis, and is an important target for new biological agents.  Bevacizumab is a humanised recombinant antibody that prevents vascular  endothelial growth factor (VEGF) receptor binding, and inhibits angiogenesis and tumour growth.

アバスチン 生産企業

Global(137)Suppliers

216974-75-3, アバスチン キーワード