こはく酸1-(ナトリウム)4-(3,20-ジオキソ-5β-プレグナン-21-イル)

こはく酸1-(ナトリウム)4-(3,20-ジオキソ-5β-プレグナン-21-イル) 化学特性,用途語,生産方法

• Originator

  Viadril,Pfizer,US,1957

• Manufacturing Process

  A solution of 20 g of desoxycorticosterone in 190 ml of absolute ethanol was stirred in an atmosphere of hydrogen in the presence of 1.68 g of 25% palladium on calcium carbonate catalyst. After 20 hours, approximately 1 molar equivalent of hydrogen had been absorbed and hydrogen uptake had ceased. The catalyst was removed by filtration and the filtrate evaporated in vacuo to yield 20 g of nearly pure product, MP 135°C to 140°C. The crude product was demonstrated to be free of starting material by paper chromatography. A highly purified product was obtained by recrystallization from acetone-water with cooling in an ice bath, yield 14.5 g, MP 152°C to 154°C. The product was characterized by analysis and by absence of ultraviolet absorption.
  A solution of 14 g of 21-hydroxypregnane-3,20-dione and of 14 g of recrystallized succinic anhydride in 140 ml of dry pyridine was allowed to stand at room temperature for 18 hours, then cooled in an ice bath and poured in a fine stream into 1.5 liters of ice water. Excess pyridine was neutralized with 3N hydrochloric acid and the solution further diluted with 2 liters of ice water. The precipitated product was filtered, washed with water and dried in vacuo at 50°C affording 18 g of solid MP 192°C to 195°C. Recrystallization of a small sample afforded analytically pure material, MP 200°C.

• Therapeutic Function

  Anesthetic

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こはく酸1-(ナトリウム)4-(3,20-ジオキソ-5β-プレグナン-21-イル) 生産企業

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