3-[(R)-2-ヒドロキシ-3-メチルブチル]-4,8-ジメトキシ-1-メチル-2(1H)-キノリノン

3-[(R)-2-ヒドロキシ-3-メチルブチル]-4,8-ジメトキシ-1-メチル-2(1H)-キノリノン 化学特性,用途語,生産方法

• 説明

  This alkaloid was first described by Boorsma who obtained it from the bark of Lunasia costulata Miq (Syn. L. amara Blanco). The base is a quinolone derivative and crystallizes as colourless needles from AcOEt. It is dextrorotatory having [α]²⁴_D + 30.1 ° and [α]²⁴₄₃₆ + 81.8°. Boorsma gives a specific rotation of [α]²⁸_D + 31.6°. The solutions of the alkaloid show a weak blue fluorescence in artificial light. A crystalline perchlorate is known, m.p. 146-8°C and 193-5°C after intermediate solidification. This salt is also dextrorotatory with [α]²⁵_{58925436+ 60.7°. The structure has been demonstrated to be 3-(2-hydroxy-3- methylbutyl)-4: 8-dimethoxy-l-methyl-2-quinolone. The alkaloid described under this name by Dieterle and Beyl appears to be identical with lunamarine (q.v.).}

• 参考文献

  Boorsma., Meded. Lands. Plant., 31, 13, 126 (1899)
  Boorsma.,Bull. Inst. Bot. Buit., No. 31, 8, 25 (1904)
  Dieterle, Beyl., Arch. Pharm., 275, 174 (1937)
  Steldt, Chen.,J. Amer. Pharm. Assoc., 32, 107 (1943)
  Goodwin, Horning.,J. Amer. Chem. Soc., 81, 1908 (1959)
  Clarke, Grundon., Chem. & Ind., 556 (1962)
  Clarke, Grundon.,J. Chem. Soc., 438 (1964)

3-[(R)-2-ヒドロキシ-3-メチルブチル]-4,8-ジメトキシ-1-メチル-2(1H)-キノリノン 生産企業

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