Chemical Properties
white to light cream powder
Uses
Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.
Uses
antihistaminic, hypnotic
Uses
H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.
Definition
ChEBI: Doxylamine succinate is an organic molecular entity.
brand name
Decapryn (Sanofi Aventis); Unisom (Pfizer).
General Description
The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.
General Description
White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.
Air & Water Reactions
Water soluble.
Health Hazard
SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.
Fire Hazard
Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.
Biochem/physiol Actions
H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.
