IKK 16
- Product NameIKK 16
- CAS873225-46-8
- CBNumberCB92666638
- MFC28H29N5OS
- MW483.63
- MDL NumberMFCD23704180
- MOL File873225-46-8.mol
Chemical Properties
storage temp. | Store at -20°C |
solubility | ≥23.05 mg/mL in DMSO; ≥11.3 mg/mL in EtOH with ultrasonic; insoluble in H2O |
form | solid |
IKK 16 Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
TRC B207020 | 10mg | $185 | [4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone |
Buy |
ApexBio Technology B1586 | 10mg | $126 | IKK-16(IKKInhibitorVII) |
Buy |
ChemScene CS-1282 | 10mg | $174 | IKK16 99.09% |
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ApexBio Technology B1586 | 50mg | $494 | IKK-16(IKKInhibitorVII) |
Buy |
ChemScene CS-1282 | 50mg | $714 | IKK16 99.09% |
Buy |
IKK 16 Chemical Properties,Usage,Production
Uses
IKK-16 is a potential novel IκB kinase 2 (IKK2) inhibitor used in the treatment of various immune/inflammatory disorders.Definition
ChEBI: [4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.Biological Activity
ikk-16 (ikk inhibitor vii) is a novel inhibitor of iκb kinase (ikk) with the ic50 values of 0.04μm, 0.2μm and 0.07μm for ikk2, ikk1 and ikk complex, respectively [1].ikk-16 (ikk inhibitor vii) is a 2-benzamido-pyrimidines and selective inhibitor of iκb kinase (ikk). ikk-16 has been reported to effectively inhibit tnfα release into plasma upon lps-challenge in the rat. in addition, ikk-16 has been found to be active at thioglycollate-induced peritonitis model in the mouse. furthermore, ikk-16 has revealed to be an orally bio-available in rats and mice, and have significant in vivo activity in an acute model of cytokine release [1].target
IKK-2References
[1] waelchli r1, bollbuck b, bruns c, buhl t, eder j, feifel r, hersperger r, janser p, revesz l, zerwes hg, schlapbach a.design and preparation of 2-benzamido-pyrimidines as inhibitors of ikk. bioorg med chem lett. 2006 jan 1;16(1):108-12. epub 2005 oct 19.Preparation Products And Raw materials
IKK 16 Supplier
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IKK 16 Spectrum
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