5H-Benzocycloheptene-8-carboxylic acid, 3,4,6-trihydroxy-2-methoxy-5-oxo-, hexyl ester

Description

CU CPT 22 is an antagonist of toll-like receptor 1 (TLR1) and TLR2 heterodimers (TLR1/TLR2; K_i = 0.41 μM). It inhibits nitric oxide (NO) production induced by the TLR2 agonist Pam₃CSK₄ in RAW 264.7 cells (IC₅₀ = 0.58 μM). It is selective for TLR1/TLR2 over TLR2/TLR6 and TLR3, -4, and -7 homodimers, as well as 10 kinases at 0.5 μM. CU CPT 22 (8 μM) inhibits Pam₃CSK₄-induced release of TNF-α and IL-1β in RAW 264.7 cells by 60 and 95%, respectively.

storage

Store at -20°C