Chemical Properties
White or yellowish-white powder or crystals.
Uses
Tiotropium Bromide hydrate is a hydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. Although tiotropium Bromide (Spiriva; Tiova; BA 679BR; tiopropium) doe
Definition
ChEBI: Tiotropium bromide hydrate is a hydrate that is the monohydrate form of tiotropium bromide. Used for maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease. It has a role as a muscarinic antagonist and a bronchodilator agent.
Clinical Use
Maintenance treatment of chronic obstructive pulmonary disease
Drug interactions
Potentially hazardous interactions with other drugs
Avoid administration with other anti-cholinergic
drugs.
Anti-arrhythmics: increased risk of antimuscarinic
side effects with disopyramide.
Metabolism
Tiotropium is excreted largely unchanged in the urine, although it may undergo some metabolism by non-enzymatic cleavage and by the cytochrome P450 isoenzymes CYP2D6 and CYP3A4.
