Description
Milbemycin A
3 oxime is an anthelmintic, a derivative of milbemycin A
3 , and a component of milbemycin oxide . It reduces the number of microfilariae of the heartworm
D. immitis in the blood of naturally infested dogs by 85.2% when administered at a dose of 0.05 mg/kg. Formulations containing milbemycin A
3 oxime, in combination with milbemycin A
4 oxime, have been used in the treatment of parasitic infections in dogs.
Uses
Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.
