4-Benzylpiperidin

Bezeichnung:4-Benzylpiperidin

CAS-Nr31252-42-3

Englisch Name:4-Benzylpiperidine

CBNumberCB9141122

SummenformelC12H17N

Molgewicht175.27

MOL-Datei31252-42-3.mol

Synonyma

4-Benzylpiperidin

4-Benzylpiperidin physikalisch-chemischer Eigenschaften

Schmelzpunkt	6-7 °C (lit.)
Siedepunkt	279 °C (lit.)
Dichte	0.997 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.537(lit.)
Flammpunkt	>230 °F
storage temp.	Store below +30°C.
Aggregatzustand	Viscous Liquid
pka	10.58±0.10(Predicted)
Farbe	Clear colorless to yellow
BRN	132339
CAS Datenbank	31252-42-3(CAS DataBase Reference)
EPA chemische Informationen	Piperidine, 4-(phenylmethyl)- (31252-42-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	TM4728000
TSCA	Yes
HazardClass	IRRITANT
HS Code	29333990

Gefahreninformationscode (GHS)

4-Benzylpiperidine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
clear colourless to yellow viscous liquid.
Verwenden
4-Benzylpiperidine was studied as acid corrosion inhibitor for iron. It was also used to study potential utility of dopamine-welective releaser as a treatment for cocaine dependence. In an assay of cocaine discrimination, 4-Benzylpiperidine had the most rapid onset and shortest duration of action.
synthetische
4-Benzylpiperidine can be prepared by reacting 4-cyanopyridine with toluene. Catalytic hydrogenation of the pyridine ring then completes the synthesis.
Application
Reactant for synthesis of:
Antiproliferatives
GABA uptake inhibitors
Pyridines
Histamine H3 antagonists
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution
Synthesis Reference(s)
Synthesis, p. 741, 1980 DOI: 10.1055/s-1980-29196
Allgemeine Beschreibung
4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.
Biochem/physiol Actions
4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B, with IC50 values of 0.02 mM and 2 mM respectively. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively . It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.

4-Benzylpiperidine Upstream-Materialien And Downstream Produkte

4-Benzylpiperidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

31252-42-3, 4-Benzylpiperidine Verwandte Suche:

Send Inquriy