Purin-6(1H)-on

Bezeichnung:Purin-6(1H)-on

CAS-Nr68-94-0

Englisch Name:6-Hydroxypurine

CBNumberCB5378579

SummenformelC5H4N4O

Molgewicht136.11

MOL-Datei68-94-0.mol

Synonyma

Purin-6(1H)-on

Purin-6(1H)-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300 °C (lit.)
Siedepunkt	250.36°C (rough estimate)
Dichte	1.4295 (rough estimate)
Brechungsindex	1.8500 (estimate)
storage temp.	2-8°C
Löslichkeit	1 M NaOH: 25 mg/mL
Aggregatzustand	powder
pka	8.7(at 25℃)
Farbe	Colorless to yellow to brown, darken on storage with no loss of purity
Geruch (Odor)	Odorless
Wasserlöslichkeit	practically insoluble
Merck	14,4869
BRN	5811
InChIKey	FDGQSTZJBFJUBT-UHFFFAOYSA-N
LogP	-0.910 (est)
CAS Datenbank	68-94-0(CAS DataBase Reference)
NIST chemische Informationen	Hypoxanthine(68-94-0)
EPA chemische Informationen	Hypoxanthine (68-94-0)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38-22-40
S-Sätze:	22-24/25-37/39-26-36
WGK Germany	3
RTECS-Nr.	UP0791000
Hazard Note	Harmful
TSCA	Yes
HS Code	29335990
Toxizität	LD50 intraperitoneal in mouse: 750mg/kg

Gefahreninformationscode (GHS)

6-Hydroxypurine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.
Chemische Eigenschaften
White to off-white powder
Verwenden
Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. The compound has been used in studies as in indicator, along with uric acid and allantoin , of in vivo free radical reactions. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol ? (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.
Verwenden
Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.
Verwenden
A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals
Definition
ChEBI: A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
Allgemeine Beschreibung
Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).
Biochem/physiol Actions
Hypoxanthine?is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.
Sicherheitsprofil
Moderately toxic by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of Nox
läuterung methode
Crystallise it from hot water and dry it at 105o. [Beilstein 26 II 252, 26 III/IV 2081.]

6-Hydroxypurine Upstream-Materialien And Downstream Produkte

Purin-6(1H)-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

68-94-0, 6-Hydroxypurine Verwandte Suche:

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