生物活性 靶点 体外研究 二氢丹参酮 试剂级价格
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二氢丹参酮

二氢丹参酮,20958-18-3,结构式
二氢丹参酮
  • CAS号:20958-18-3
  • 英文名:Dihydrotanshinone
  • 中文名:二氢丹参酮
  • CBNumber:CB91247335
  • 分子式:C18H14O3
  • 分子量:278.3
  • MOL File:20958-18-3.mol
二氢丹参酮化学性质
  • 沸点 :470.4±45.0 °C(Predicted)
  • 密度 :1.32±0.1 g/cm3(Predicted)
  • 储存条件 :Store at -20°C
  • 溶解度 :DMSO : 3.33 mg/mL (11.97 mM; ultrasonic and warming and heat to 40°C)H2O : < 0.1 mg/mL (insoluble)
  • 形态 :powder
  • 颜色 :Red

二氢丹参酮性质、用途与生产工艺

  • 生物活性 Dihydroisotanshinone I是一种来自应用广泛的传统中药丹参的活性物质。
  • 靶点

    STAT3

  • 体外研究

    Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin. It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1. Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently.

  • 用途  具有抗菌,抗真菌活性,对金黄色葡萄球菌、人型结核杆菌、分支杆菌、真皮菌等都有一定的抑制作用。还有抑制血小板聚集、抗氧化剂、扩张冠状血管等活性。
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二氢丹参酮 试剂级价格
  • 更新日期:2022/07/01
  • 产品编号:HY-B1919
  • 产品名称:二氢丹参酮 Dihydroisotanshinone I
  • CAS编号:20958-18-3
  • 包装:5mg
  • 价格:1800元
  • 更新日期:2022/07/01
  • 产品编号:HY-B1919
  • 产品名称:二氢丹参酮 Dihydroisotanshinone I
  • CAS编号:20958-18-3
  • 包装:10mM * 1mLin DMSO
  • 价格:2380元
二氢丹参酮生产厂家
  • 公司名称:MedChemexpress LLC
  • 联系电话:021-58955995
  • 电子邮件:sales@medchemexpress.cn
  • 国家:美国
  • 产品数:4863
  • 优势度:58
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