醛固酮

生物活性靶点体外研究体内研究醛固酮试剂级价格

醛固酮

CAS号:52-39-1
英文名:ALDOSTERONE
中文名:醛固酮
CBNumber:CB8431679
分子式:C21H28O5
分子量:360.45
MOL File:52-39-1.mol

醛固酮化学性质

熔点 :170-172°C
比旋光度 :D23 +152.2° (anhydr; c = 2 in acetone); D25 +161° (c = 0.1 in chloroform)
沸点 :412.46°C (rough estimate)
密度 :1.28
折射率 :1.6120 (estimate)
闪点 :2℃
储存条件 :Sealed in dry,Room Temperature
溶解度 :Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
酸度系数(pKa) :12.98±0.10(Predicted)
形态 :Crystalline Powder
颜色 :White
水溶解性 :51.18mg/L(37 ºC)
Merck :13,224
BRN :3224996
CAS 数据库 :52-39-1(CAS DataBase Reference)
EPA化学物质信息 :Aldosterone (52-39-1)

安全信息

危险品标志 :Xi,Xn,F
危险类别码 :36/37/38-36-20/21/22-11
安全说明 :22-24/25-36-26-36/37-16
危险品运输编号 :UN 1648 3 / PGII
WGK Germany :3
RTECS号 :TU4523000
F :22-24-25
海关编码 :29372900

醛固酮性质、用途与生产工艺

生物活性 Aldosterone 是原发性盐皮质激素。Aldosterone 是一种类固醇激素，通过肾上腺皮质的肾小球区 (ZG) 对肾素-血管紧张素系统激活 (RAS) 或高钾饮食反应而合成和分泌。Aldosterone 活性在细胞水平上依赖于胞浆/核盐皮质激素受体 (MR) 的结合和激活。
靶点

Human Endogenous Metabolite
体外研究

Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner.

体内研究

Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP).
Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice.

Animal Model:	Forty male Wistar rats
Dosage:	1 mg/Kg (+1% NaCl)
Administration:	i.h.; once daily for 3 weeks
Result:	Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals.