离子霉素

离子霉素化学性质

沸点 :817.2±65.0 °C(Predicted)
密度 :1.072±0.06 g/cm3(Predicted)
储存条件 :−20°C
溶解度 :Soluble to 10 mM in Ethanol and to 10 mM in DMSO.
形态 :Waxy solid
酸度系数(pKa) :4.77±0.10(Predicted)
颜色 :Yellow
BRN :3642126
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

安全信息

离子霉素性质、用途与生产工艺

生物活性 Ionomycin (SQ23377) 是一种有效的，选择性的钙离子载体 (calcium ionophore)，也是一种由 Streptomyces conglobatus 产生的抗生素。Ionomycin (SQ23377) 对二价阳离子具有高度特异性 (Ca>Mg>Sr=Ba)。Ionomycin (SQ23377) 促进细胞凋亡。Ionomycin (SQ23377) 还诱导蛋白激酶C (PKC) 激活。
靶点

Calcium ionophore
体外研究

Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus .
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca ²⁺ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.

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