生物活性 靶点 体外研究 体内研究 环芬尼 试剂级价格
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环芬尼

环芬尼,2624-43-3,结构式
环芬尼
  • CAS号:2624-43-3
  • 英文名:Cyclofenil
  • 中文名:环芬尼
  • CBNumber:CB5212631
  • 分子式:C23H24O4
  • 分子量:364.44
  • MOL File:2624-43-3.mol
环芬尼化学性质
  • 熔点 :135-136°
  • 沸点 :415.62°C (rough estimate)
  • 密度 :1.0986 (rough estimate)
  • 折射率 :1.4433 (estimate)
  • 储存条件 :2-8°C
  • 溶解度 :DMSO: 10 mg/mL at 60 °C, soluble
  • 形态 :solid
  • 颜色 :White to Off-White
  • CAS 数据库 :2624-43-3(CAS DataBase Reference)
安全信息
  • WGK Germany :2
  • RTECS号 :GO7550000
  • 毒性 :LD50 oral in rat: > 12gm/kg

环芬尼 MSDS


[4-[(4-Acetyloxyphenyl)-cyclohexylidenemethyl]phenyl] acetate

环芬尼性质、用途与生产工艺

  • 生物活性 Cyclofenil 是一种选择性雌激素受体 (estrogen receptor) 调节剂和排卵诱导剂。Cyclofenil 对 Vero 细胞中的登革热病毒复制具有抑制作用,EC50 为 1.62 μM。 Cyclofenil 具有抗登革热病毒的活性。
  • 靶点
    TargetValue
    ERβ
    ()
    ERα
    ()
  • 体外研究

    Cyclofenil shows an inhibitory effect on dengue virus (DENV) replication in mammalian cells but not in mosquito cells.
    Cyclofenil also inhibits the replication of Zika virus. A time-of-addition assay suggested that Cyclofenil may interfere with two stages of the Dengue virus (DENV) life cycle: the translation-RNA synthesis and assembly-maturation stages. The level of intracellular infectious particles decreased more drastically after treatment with Cyclofenil than the viral RNA level do, indicating that the assembly-maturation stage might be the main target of Cyclofenil.

  • 体内研究

    The number of estrogen receptors α (ERα) and β (ERβ)-immunoreactive (-ir) cells is determined of each stage of the estrous cycle in intact rats. Additionally, the effects of blocking ERα and ERβ on ovulation rate on diestrus-2 or proestrus day through the microinjection of methyl-piperidino-pyrazole (MPP) or Cyclofenil in either side of preoptic-anterior hypothalamic area (POA-AHA) are evaluated. The number of ERα-ir and ERβ-ir cells in POA-AHA varied in each phase of estrous cycle. Either MPP or Cyclofenil in the right side of POA-AHA on diestrus-2 day reduced the ovulation rate, while at proestrus day it was decreased in rats treated in either side with MPP, and in those treated with Cyclofenil in the left side. MPP or Cyclofenil produced a decrease in the surge of luteinizing hormone levels (LH) and an increase in progesterone and follicle stimulating hormone (FSH).

环芬尼上下游产品信息
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环芬尼 试剂级价格
  • 更新日期:2024/01/25
  • 产品编号:HY-W011100
  • 产品名称:环芬尼 Cyclofenil
  • CAS编号:2624-43-3
  • 包装:50mg
  • 价格:700元
  • 更新日期:2024/01/25
  • 产品编号:HY-W011100
  • 产品名称:环芬尼 Cyclofenil
  • CAS编号:2624-43-3
  • 包装:10mM * 1mLin DMSO
  • 价格:770元
环芬尼生产厂家
  • 公司名称:TargetMol中国(陶术生物)
  • 联系电话:021-33632979 15002134094
  • 电子邮件:marketing@targetmol.com
  • 国家:中国
  • 产品数:7934
  • 优势度:58
  • 公司名称:EMMX Biotechnology LLC
  • 联系电话:888-539-0666
  • 电子邮件:info@emmx.com
  • 国家:美国
  • 产品数:8449
  • 优势度:60
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