生物活性 体外研究 体内研究 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 试剂级价格
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ChemicalBook  CAS数据库列表  11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE

11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE

生物活性 体外研究 体内研究 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 试剂级价格
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE,1482-50-4,结构式
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
  • CAS号:1482-50-4
  • 英文名:11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
  • 中文名:11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
  • CBNumber:CB4757474
  • 分子式:C21H32O5
  • 分子量:364.48
  • MOL File:1482-50-4.mol
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE化学性质
  • 熔点 :>173°C (dec.)
  • 沸点 :544.5±50.0 °C(Predicted)
  • 密度 :1.249±0.06 g/cm3(Predicted)
  • 储存条件 :Refrigerator
  • 溶解度 :DMSO (Slightly), Methanol (Slightly)
  • 形态 :Solid
  • 酸度系数(pKa) :12.50±0.70(Predicted)
  • 颜色 :White to Off-White

11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE性质、用途与生产工艺

  • 生物活性 5β-Dihydrocortisol，氢化可的松 (Cortisol) 的代谢产物，是潜在的盐皮质激素。5β-Dihydrocortisol 可以增强糖皮质激素的活性以提高眼压。5β-Dihydrocortisol 可引起乳腺癌细胞凋亡。
  • 体外研究

    5β-Dihydrocortisol (10-100 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC 50 of 27.59 μM.
    5β-Dihydrocortisol (14 μM; 24 h) induces 35.6% early apoptosis and 2.5% late apoptosis in MCF-7 cells.
    5β-Dihydrocortisol (1-10 μM; 48 h) quenches the intrinsic fluorescence of human serum albumin (HAS) with a maximum emission peak at 360 nm, with no shift in fluorescence peak.

    Cell Viability Assay

    Cell Line: MCF-7 and HEK 293 cells
    Concentration: 10, 20, 40, 60, 80, 100 μM
    Incubation Time: 48 hours
    Result: Inhibited the viability of MCF-7 cells in a dose-dependent manner.
    No toxicity in terms of cell viability was observed with HEK293 cell line.

    Apoptosis Analysis

    Cell Line: MCF-7 cells
    Concentration: 14 μM
    Incubation Time: 24 hours
    Result: Induced 35.6% and 2.5% of early and late apoptosis.
  • 体内研究

    5β-Dihydrocortisol (0.1-1.0%; 18 d) potentiates the action of topically applied Dexamethasone (0.06%) in raising the intraocular pressure (IOP) in young rabbits.

11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE上下游产品信息
上游原料
下游产品
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 试剂级价格
  • 更新日期：2024/04/30
  • 产品编号：HY-N3995
  • 产品名称：11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 5β-Dihydrocortisol
  • CAS编号：1482-50-4
  • 包装：5mg
  • 价格：2800元
  • 更新日期：2024/04/30
  • 产品编号：HY-N3995
  • 产品名称：11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 5β-Dihydrocortisol
  • CAS编号：1482-50-4
  • 包装：10mM * 1mLin DMSO
  • 价格：3080元
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE生产厂家
  • 公司名称：北京百灵威科技有限公司
  • 联系电话：010-82848833 400-666-7788
  • 电子邮件：jkinfo@jkchemical.com
  • 国家：中国
  • 产品数：96815
  • 优势度：76
  • 公司名称：Aladdin Scientific Corporation
  • 联系电话：+1-833-552-7181
  • 电子邮件：sales@aladdinsci.com
  • 国家：美国
  • 产品数：52927
  • 优势度：58
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