顺式-8，11，14-二十烷三烯酸甲酯

生物活性靶点体外研究体内研究顺式-8，11，14-二十烷三烯酸甲酯试剂级价格

顺式-8，11，14-二十烷三烯酸甲酯

CAS号:1783-84-2
英文名:CIS-8,11,14-EICOSATRIENOIC ACID
中文名:顺式-8，11，14-二十烷三烯酸甲酯
CBNumber:CB4667988
分子式:C20H34O2
分子量:306.48
MOL File:1783-84-2.mol

顺式-8，11，14-二十烷三烯酸甲酯化学性质

沸点 :200°C(lit.)
密度 :0.917±0.06 g/cm3(Predicted)
折射率 :n20/D 1.478(lit.)
闪点 :144 °F
储存条件 :-20°C
溶解度 :chloroform: 50 mg/mL, clear, colorless
酸度系数(pKa) :4.77±0.10(Predicted)
形态 :Liquid
颜色 :Colourless to Light Yellow
BRN :1796533
稳定性 :Light Sensitive

安全信息

安全说明 :23-24/25
危险品运输编号 :NA 1993 / PGIII
WGK Germany :3
RTECS号 :JX3880000
F :8-10-23
海关编码 :2916.19.3000

顺式-8，11，14-二十烷三烯酸甲酯性质、用途与生产工艺

生物活性 Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) 是 20 个碳的 ω-6 脂肪酸，具有抗炎和抗增殖活性。Dihomo-γ-linolenic acid 能减弱载脂蛋白 E 缺陷小鼠模型模型的动脉粥样硬化。
靶点

Human Endogenous Metabolite

体外研究

Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages.
Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727.
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages.
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation.
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages.
Dihomo-γ-linolenic acid modulates mitochondrial respiration.
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.

Western Blot Analysis

Cell Line:	THP-1 macrophages
Concentration:	50 μM (pre-treated)
Incubation Time:	24 hours
Result:	Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727.

体内研究

Dihomo-γ-linolenic acid (8 mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.

Animal Model:	Female nude mice (48 four-week old)
Dosage:	8 mg/mouse
Administration:	Oral gavage, twice a week, for 35 days
Result:	Suppressed metastasis potential in D5D-KD tumors.