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ChemicalBook  CAS数据库列表  壳二孢氯素

壳二孢氯素

生物活性 靶点 体外研究 体内研究
壳二孢氯素,26166-39-2,结构式
壳二孢氯素
  • CAS号:26166-39-2
  • 英文名:ascochlorin
  • 中文名:壳二孢氯素
  • CBNumber:CB01364846
  • 分子式:C23H29ClO4
  • 分子量:404.931
  • MOL File:26166-39-2.mol
壳二孢氯素化学性质
  • 熔点 :172-174 °C
  • 沸点 :556.9±39.0 °C(Predicted)
  • 密度 :1.199±0.06 g/cm3(Predicted)
  • 储存条件 :-20°C
  • 溶解度 :DMSO: soluble
  • 形态 :A powder
  • 酸度系数(pKa) :6.26±0.50(Predicted)
安全信息
  • WGK Germany :3
  • 毒性 :mouse,LD50,intraperitoneal,20mg/kg (20mg/kg),Journal of Antibiotics. Vol. 21, Pg. 539, 1968.

壳二孢氯素性质、用途与生产工艺

  • 生物活性 Ascochlorin (Ilicicolin D)，异戊二烯类抗生素。Ascochlorin 主要通过抑制 STAT3 信号级联介导其抗肿瘤作用。Ascochlorin 诱导细胞凋亡 (apoptosis)。具有抗炎活性。
  • 靶点

    STAT3

    Apoptosis

  • 体外研究

    Ascochlorin (Ilicicolin D) (10-50 μM; 24-72 hours) inhibits the viability of HepG2, HCCLM3 and Huh7 cells in a time and dose dependent manner.
    Ascochlorin (50 μM; 48 hours) induces apoptosis in HCC cells.
    Ascochlorin (1-50 μM) significantly suppresses the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and decreases the gene expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner. Ascochlorin inhibits the mRNA expression and the protein secretion of interleukin (IL)-1β and IL-6 but not tumor necrosis factor (TNF)-α in LPS-stimulated RAW 264.7 macrophage cells. Ascochlorin suppresses nuclear translocation and DNA binding affinity of nuclear factor-κB (NF-κB). Ascochlorin down-regulates phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2) and p-p38.

    Cell Viability Assay

    Cell Line: HepG2, HCCLM3, Huh7 cells
    Concentration: 10, 25, 50 μM
    Incubation Time: 24, 48, 72 hours
    Result: Inhibit the viability of three different HCC cell lines tested (HepG2, HCCLM3 and Huh7) in a time and dose dependent manner.

    Western Blot Analysis

    Cell Line: HepG2 cells
    Concentration: 50 μM
    Incubation Time: 48 hours
    Result: Inhibited expression of the cell cycle regulator protein cyclin D1, the anti-apoptotic proteins Bcl-2, Mcl-1, survivin and XIAP, and the invasive gene product MMP-9.
  • 体内研究

    Ascochlorin (Ilicicolin D) (2.5-5 mg/kg; i.p.; day 0, 1, 2, 3, 13, 15, 17, 20, 22, 24, 27, 29 and 31) inhibits tumor growth in an orthotopic HCC mouse model.

    Animal Model: Eight week-old athymic balb/c nude female mice (HCCLM3-Luc2 tumors)
    Dosage: 2.5 mg/kg, 5 mg/kg
    Administration: I.p.; day 0, 1, 2, 3, 13, 15, 17, 20, 22, 24, 27, 29 and 31
    Result: Induced significant inhibition of tumor growth.
壳二孢氯素上下游产品信息
上游原料
下游产品
壳二孢氯素生产厂家
  • 公司名称：Novachemistry
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  • 公司名称：TargetMol Chemicals Inc.
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  • 电子邮件：marketing@targetmol.com
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  • 公司名称：浙江珲达生物科技有限公司
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  • 电子邮件：jiangnan@huidabiotech.com
  • 国家：中国
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