69552-46-1
基本信息
Carba pgx
Carba-PGI2
CARBACYCLIN
Carbacycline
6A-Carba-pgi2
6,9-Methano-pgi2
6,9-Methano pgi2
CARBACYCLIC PGI2
CARBOCYCLIC PGI2
物理化学性质
| 熔点 | 65-67℃ |
| 沸点 | 514.8±50.0 °C(Predicted) |
| 密度 | 1.177±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 在乙醇中溶解度为 20mg/ml。 |
| 酸度系数(pKa) | 4.77±0.10(Predicted) |
| 形态 | 固体 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H312-H332 |
| 防范说明 | P261-P280h-P301+P312a-P304+P340-P321-P501a |
| 危险品标志 | Xn |
| 危险类别码 | 20/21/22 |
| 安全说明 | 22-36 |
| WGK Germany | 3 |
CARBACYCLIN价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-112322 | CARBACYCLIN Carbacyclin | 69552-46-1 | 1mg | 6200元 |
常见问题列表
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PGI 2 Receptor
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Carbacyclin is an agonist of prostacyclin (PGI2) receptor. Carbacyclin acts as an inhibitor of platelet aggregation induced by ADP or collagen in vitro. Carbacyclin is a PGI2 analogue, activates CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Carbacyclin (0.02 μM to 20 μM) activates the IP receptor signaling pathway via PKA, and such an effect is inhibited by H-89, a PKA inhibitor. Carbacyclin (0.02-80 μM) increases PPRE promoter activity via PPARδ independent of the IP receptor signaling pathway in cardiomyocytes.
Carbacyclin is 0.03 times as active as prostacyclin on inhibiting platelet aggregation in human, dog or rabbit plasma. Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression in murine heart.