2624-43-3
基本信息
双醋环烷
环己基亚甲基二苯酚二乙酸酯
4-(CYCLOHEXYLIDENEMETHYLENE)-BIS-PHENOL DIACETATE
CYCLOFENIL
4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)-phenoacetate
alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)-p-cresodiacetate
bis-(p-acetoxyphenyl)-cyclohexylidenemethane
bis-(p-hydroxyphenyl)-cyclohexylidenemethanediacetate
cyclofenyl
cyclophenil
cyclophenyl
f6066
fertodur
h3452
ici48213
oginex
ondogyne
ondonid
sexadieno
sexovar
(Cyclohexylidenemethanediyl)dibenzene-4,1-diyl diacetate
物理化学性质
| 熔点 | 135-136° |
| 沸点 | 415.62°C (rough estimate) |
| 密度 | 1.0986 (rough estimate) |
| 折射率 | 1.4433 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO: 10 mg/mL at 60 °C, soluble |
| 形态 | solid |
| 形态 | 固体 |
| 颜色 | 白色至灰白色 |
| CAS 数据库 | 2624-43-3(CAS DataBase Reference) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319 |
| 防范说明 | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| WGK Germany | 2 |
| RTECS号 | GO7550000 |
| 毒性 | LD50 oral in rat: > 12gm/kg |
知名试剂公司产品信息
环芬尼价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-W011100 | 环芬尼 Cyclofenil | 2624-43-3 | 50mg | 700元 |
| 2024/01/25 | HY-W011100 | 环芬尼 Cyclofenil | 2624-43-3 | 10mM * 1mLin DMSO | 770元 |
| 2024/01/25 | HY-W011100 | 环芬尼 Cyclofenil | 2624-43-3 | 100mg | 1100元 |
常见问题列表
| Target | Value |
|
ERβ
() | |
|
ERα
() |
Cyclofenil shows an inhibitory effect on dengue virus (DENV) replication in mammalian cells but not in mosquito cells.
Cyclofenil also inhibits the replication of Zika virus. A time-of-addition assay suggested that Cyclofenil may interfere with two stages of the Dengue virus (DENV) life cycle: the translation-RNA synthesis and assembly-maturation stages. The level of intracellular infectious particles decreased more drastically after treatment with Cyclofenil than the viral RNA level do, indicating that the assembly-maturation stage might be the main target of Cyclofenil.
The number of estrogen receptors α (ERα) and β (ERβ)-immunoreactive (-ir) cells is determined of each stage of the estrous cycle in intact rats. Additionally, the effects of blocking ERα and ERβ on ovulation rate on diestrus-2 or proestrus day through the microinjection of methyl-piperidino-pyrazole (MPP) or Cyclofenil in either side of preoptic-anterior hypothalamic area (POA-AHA) are evaluated. The number of ERα-ir and ERβ-ir cells in POA-AHA varied in each phase of estrous cycle. Either MPP or Cyclofenil in the right side of POA-AHA on diestrus-2 day reduced the ovulation rate, while at proestrus day it was decreased in rats treated in either side with MPP, and in those treated with Cyclofenil in the left side. MPP or Cyclofenil produced a decrease in the surge of luteinizing hormone levels (LH) and an increase in progesterone and follicle stimulating hormone (FSH).