2219-31-0
基本信息
硫酸-L-刀豆氨基酸
刀豆氨酸
L-硫酸刀豆氨酸
CANAVANINE SULFATE, L-
L-2-AMINO-4-(GUANIDIOOXY)BUTYRIC ACID SULFATE
L-ALPHA-AMINO-GAMMA-(GUANIDINOOXYL)-N-BUTYRIC ACID SULFATE
L-ALPHA-AMINO-GAMMA (GUANIDINOOXY)-N-BUTYRIC ACID SULFATE
L-ALPHA-AMINO-GAMMA-[GUANIDINOOXY]-N-BUTYRIC ACID SULFATE SALT
L-CANAVANINE SULFATE
L-CANAVANINE SULFATE SALT
L-CANAVANINE SULPHATE
o-[(aminoiminomethyl)amino]-l-homoserinsulfate(1:1)
canavanine sulphate
L-canavanine sulfate crystalline
L-Canavanine Sulfate, Canavalia ensiformis
l-α-amino-γ-(guanidinooxy)butyric acid sulfate salt
CANAVANINE SULFATE, L-(RG)
L-CANAVANINE SULFATE HYDRATE
物理化学性质
| 熔点 | 160-165 °C (dec.) |
| 储存条件 | 2-8°C |
| 溶解度 | H2O: 100 mg/mL |
| 形态 | powder |
| 形态 | 粉末 |
| 颜色 | white |
| 颜色 | 白色 |
| BRN | 6121291 |
| 稳定性 | 吸湿性 |
| CAS 数据库 | 2219-31-0(CAS DataBase Reference) |
| EPA化学物质信息 | L-Canavanine sulfate (2219-31-0) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H332-H312-H302 |
| 防范说明 | P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312 |
| 危险品标志 | Xn |
| 危险类别码 | R20/21/22 |
| 安全说明 | S36 |
| 危险品运输编号 | 2811 |
| WGK Germany | 3 |
| 海关编码 | 2925290090 |
知名试剂公司产品信息
L-刀豆氨酸硫酸盐价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-B1581A | L-刀豆氨酸硫酸盐 L-Canavanine sulfate | 2219-31-0 | 50mg | 400元 |
| 2024/01/25 | HY-B1581A | L-刀豆氨酸硫酸盐 L-Canavanine sulfate | 2219-31-0 | 10mM * 1mLin Water | 440元 |
| 2024/01/25 | HY-B1581A | L-刀豆氨酸硫酸盐 L-Canavanine sulfate | 2219-31-0 | 100mg | 600元 |
常见问题列表
NO synthase
L-Canavanine sulfate (L-CAV) causes only a limited degree of cytotoxicity in HeLa, Hep G2, and SK-HEP-1 cells when given alone in arginine-rich media with IC 50 values ranging from 5 to 10 mM. In HaCaT keratinocyte cell line, IC 50 of L-Canavanine sulfate exceeds the concentration of 10 mM, indicating low cytotoxicity in normal cells in vitro . In arginine-free media, IC 50 of L-Canavanine sulfate in HeLa, Hep G2, and SK-HEP-1 cells are 0.21±0.04; 0.64±0.16; and 1.18±0.14 mM, respectively. L-Canavanine sulfate, which is hardly toxic alone, potentiates the cytotoxicity of vinblastine (VIN) and paclitaxel (PTX) in HeLa and hepatocellular carcinoma cells.
Administration of L-Canavanine sulfate (100 mg/kg) produces a moderate increase in mean arterial pressure of 20 mm Hg, returns blood pressure to near basal levels and completely attenuates the lipopolysaccharide-induced hypotension. All, but one, endotoxaemic rats dosed with L-Canavanine sulfate (100 mg/kg) survive for 6 h post lipopolysaccharide, after which time the experiment is terminated (n=7). L-canavanine inhibits DNA synthesis by Li 210 cells in vivo and significantly increases the lifespan of animals bearing the Li 210 leukemia. An optimal dose of 18 g/kg produces a peak increase in lifespan of 44%. The therapeutic dose range is narrow, and a dose of 24 g/kg causes death due to drug toxicity.