218137-86-1
基本信息
化合物 T10657
FAS inhibitor C75 (C-75
C75 >=98% (HPLC), powder
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE
3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-
C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid)
TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID
物理化学性质
| 沸点 | 432.1±45.0 °C(Predicted) |
| 密度 | 1.08±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO: 18 mg/mL |
| 酸度系数(pKa) | 3.08±0.40(Predicted) |
| 形态 | solid |
| 颜色 | off-white |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H335 |
| 防范说明 | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
218137-86-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-12364 | 218137-86-1 C75 | 218137-86-1 | 2 mg | 866元 |
| 2024/01/25 | HY-12364 | 218137-86-1 C75 | 218137-86-1 | 10mM * 1mLin DMSO | 1211元 |
| 2024/01/25 | HY-12364 | 218137-86-1 C75 | 218137-86-1 | 5mg | 1300元 |
常见问题列表
IC50: 35 μM (PC3 cell)
C75 inhibits PC3 cell growht with an IC 50 of 35 μM at 24 h. C75 (10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC 50 of 50 μM. (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity.
C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA.