9003-11-6
| Name | Polyethylene-polypropylene glycol |
| CAS | 9003-11-6 |
| EINECS(EC#) | 618-355-0 |
| Molecular Formula | C5H10O2 |
| MDL Number | MFCD01779632 |
| Molecular Weight | 102.132 |
| MOL File | 9003-11-6.mol |
Synonyms
f98
PEOPO
rc102
PLURONIC
Poloxamer
75-h-1400
9003-11-6
poloxalene
poloxalkol
Poloxanlene
pluronicf98
POLYOXALKOL
PEG-PPG-PEG
PLURONICL31
PPG-PEG-PPG
Lutrol? F68
Ploxamer 407
PLURONICL122
POLOXAMER213
PLURONIC31R1
PLURONIC17R1
PLURONIC17RL
PLURONIC F87
PLURONIC L108
PLURONIC L-81
POLOXAMER 124
POLOXAMER 181
POLOXAMER 182
POLOXAMER 184
POLOXAMER 188
POLOXAMER 237
POLOXAMER 331
POLOXAMER 338
POLOXAMER 407
ucon75-h-1400
PLURONIC F-68
UCON50-H-5100
UCON75-H-9500
proxanoltsl-3
Pluronic L 35
Pluronic L 42
Pluronic L 43
Pluronic L 63
Thanol E 4003
Contex W18000
Contex W55000
Lutrol? F 127
Pluronic? 10R5
Pluronic? 17R4
synperonic CAS
PLURONIC F-127
SYNPERONIC P 85
PLURONIC(R) F68
PLURONIC(R) L44
PLURONIC(R) L61
PLURONIC(R) L64
Synperonic P 94
Poloxamer188407
Symperonic L 61
Contex W series
PoloxaMer Solid
Poloxanlene 182
Pluronic? L-121
Lμtrol? micro 68
Kolliphor? P 407
Pluronic(R) 31R1
Symperonic F 108
Pluronic(R) 10R5
PoloxaMer 124 NF
Pluronic(R) L-31
Pluronic(R) L-35
Pluronic(R) L-81
Pluronic(R) 17R4
Kolliphor? P 188
UCON75-H-380,000
POLOXAMER 181 NF
POLOXAMER 184 NF
Synperonic P 104
synperonic P 123
Polyetherpolyols
PLURONIC PE 6800
PLURONIC(TM) F68
PLURONIC(TM) F87
PLURONIC(TM) L44
PLURONIC(TM) L61
PLURONIC(TM) L62
PLURONIC(TM) L64
SYNPERONIC F 108
SYNPERONIC L 121
SYNPERONIC L 122
SYNPERONIC P 105
PLURONIC(TM) L101
PLURONIC(TM) L108
PLURONIC(R) F-127
PLURONIC(TM) F127
SYNPERONIC(R) F68
SYNPERONIC(R) L61
SYNPERONIC(R)/L64
Synperonic PE?F68
Synperonic PE?L61
Synperonic PE?L64
Pluronic(R) P-123
Pluronic(R) L-121
Lμtrol? micro 127
Synperonic? PE/P84
Pluracare F 127 NF
POP/POE condensate
Tergitol (TM) L-81
ICIBLOCKCOPOLYMERA
ICIBLOCKCOPOLYMERB
lubricant50-h-5100
SYNPERONIC(R) F108
Poloxalene (500 mg)
Synperonic? PE P105
Synperonic(R) PE/P84
Polyethylene-polypro
Synperonic(R) P 94
SYNPERONIC L61PRACT.
SYNPERONIC F68PRACT.
SYNPERONIC PE(R)/F68
SYNPERONIC PE(R)/L61
synperonic pe(R)/L64
Synperonic(R) P 85
Synperonic(R) L 121
Synperonic(R) PE/L64
Synperonic(R) L 122
Synperonic(R) PE/L61
Synperonic(R) P 104
PLURONICL31SURFACTANT
PLURONICL64SURFACTANT
SYNPERONIC F108PRACT.
Synperonic(R) PE/F68
Poloxamer Solid (1 g)
Lutrol? F-68 solution
Kolliphor? P 407 micro
Kolliphor? P 188 micro
PLURONIC17R1SURFACTANT
2-methyloxirane oxirane
Poloxamer Liquid (1 mL)
Poloxamer(Lutrol-BASF)
Synperonic(R) F68 pract.
Synperonic(R) F108 pract.
Poloxamer 188, micronized
Poloxamer liquid
Poloxamer 407, micronized
Poly(ethyleneglycol)-block
PLURONIC(R) F-127 DETERGENT
Poloxamer 188 solution
Methyloxirane-oxiranepolymer
polyoxyethylene-oxy-propylene
POLY(ETHYLENEPROPYLENE)GLYCOL
POLYOXYPROPYLENEPOLYOXYETHYLENE
Pluronic(R) 10R5, PPG-PEG-PPG
PEG-PPG-PEG, Pluronic(R) L-81
PEG-PPG-PEG, Pluronic(R) L-35
PEG-PPG-PEG, Pluronic(R) L-61
Pluronic(R) 17R4, PPG-PEG-PPG
PEG-PPG-PEG, Pluronic(R) L-64
PEG-PPG-PEG, Pluronic(R) L-31
PEG-PPG-PEG, Pluronic(R) F-68
methyl-oxiranpolymerwithoxirane
PEG-PPG-PEG [average MW (5800)]
Pluronic(R) 31R1, PPG-PEG-PPG
PEG-PPG-PEG, Pluronic(R) P-123
PEG-PPG-PEG, Pluronic(R) F-108
Synperonic(R) PE P105 surfactant
Polymerofmethyloxiraneandoxirane
PEG-PPG-PEG, Pluronic(R) L-121
POLYETHYLENE-POLYPROPYLENE GLYCOL
glycols,polyethylene-polypropylene
pluronic F-127 cell culture tested
ETHYLENEOXIDE/PROPYLENEOXIDEPOLYMER
ETHYLENEOXIDE-PROPYLENEOXIDEPOLYMERS
ETHYLENEOXIDE-PROPYLENEOXIDECOPOLYMER
2-Methyl-oxirane,polyMer with oxirane
EMbedded sections of polyether F-68
PROPYLENEGLYCOL-ETHYLENEOXIDECOPOLYMER
Oxirane, methyl-, polymer with oxirane
ETHYLENEOXIDE-PROPYLENEOXIDECOPOLYMERS
PROPYLENEOXIDE-ETHYLENEOXIDECOPOLYMERS
POLY(ETHYLENE OXIDE-B-PROPYLENE OXIDE)
POLY(ETHYLENE GLYCOL-CO-PROPYLENEOXIDE)
pluronic F-68 plant cell culture tested
Polymer(ethylene oxide·propylene oxide)
glycols,polyethylene-polypropylene,rc102
ETHYLENEOXIDE-PROPYLENEOXIDEBLOCKPOLYMER
POLY(ETHYLENE GLYCOL)-BLOCK-POLY-(PROPYL
POLY(OXYETHYLENE)POLY(OXYPROPYLENE)GLYCOL
POLY(ETHYLENE GLYCOL-CO-PROPYLENE GLYCOL)
Synperonic(R) F 108 surfactant, non-ionic
polyoxypropylene oxyethyleneglycerol ether
Poly(ethylene glycol-ran-propylene glycol)
polypropylene/ polyethylene glycol copolymer
POLYOXYPROPYLENE-POLYOXYETHYLENEBLOCKCOPOLYMERS
POLYOXYETHYLENE/POLOXYPROPYLENELINEARCOPOLYMERS
POLYOXYPROPYLENEPOLYOXYETHYLENE BLOCK COPOLYMER
pluronic F-68 solution (10%) insect*cell culture
polyoxyethylene-polyoxypropylene block copolymer
POLYOXYETHYLENE/POLYOXYPROPYLENELINEARCOPOLYMERS
Pluronic F-127[R] Trade Mark of BASF [PoloxaMer]
poly(ethylene glycol)-B-poly(propylene glycol)-B-
poly(propylene glycol)-B-poly(ethylene gly-col)-
Polypropylene-polyethylene glycol: (Pluronic L-81)
PLURONIC F-68 SOLUTION (10%) INSECT*CELL CULTURE TE
PLURONIC F-127, PROTEIN GRADEDetergent, 10% Solution
POLYETHYLENE OXIDE-POLYPROPYLENE OXIDE BLOCK COPOLYMER
POLYETHYLENEGLYCOL/POLYPROPYLENEGLYCOL,MIXEDCOPOLYMERS
BLOCK COPOLYMER OF POLYETHYLENE AND POLYPROPYLENE GLYCOL
PluronicF-68,Polyoxyethylene-polyoxypropylene block copolymer
Oxirane, 2-methyl-, polymer with oxirane, ether with 1,2-propanediol (2:1)
POLY(ETHYLENE GLYCOL)-BLOCK-POLY(PROPYLENE GLYCOL)-BLOCK-POLY(ETHYLENE GLYCOL)
POLY(ETHYLENE GLYCOL)-B-POLY(PROPYLENE G LYCOL)-B-POLY(ETHYLENE GLYCOL) MN2900
POLY(ETHYLENE GLYCOL)-B-POLY(PROPYLENE G LYCOL)-B-POLY(ETHYLENE GLYCOL) MN5800
POLY(ETHYLENE GLYCOL)-B-POLY(PROPYLENE G LYCOL)-B-POLY(ETHYLENE GLYCOL) MN8400
POLY(ETHYLENE GLYCOL)-B-POLY(PROPYLENE G LYCOL)-B-POLY(ETHYLENE GLYCOL) MN1900
POLY(ETHYLENE GLYCOL)-B-POLY(PROPYLENE G LYCOL)-B-POLY(ETHYLENE GLYCOL) MN2000
POLY(ETHYLENE GLYCOL)-B-POLY(PROPYLENE G LYCOL)-B-POLY(ETHYLENE GLYCOL) MN2800
POLY(ETHYLENE GLYCOL)-B-POLY(PROPYLENE G LYCOL)-B-POLY(ETHYLENE GLYCOL) MN4400
POLY(ETHYLENE GLYCOL)-B-POLY(PROPYLENE G LYCOL)-B-POLY(ETHYLENE GLYCOL) MN1100
POLY(PROPYLENE GLYCOL)-BLOCK-POLY(ETHYLENE GLYCOL)-BLOCK-POLY(PROPYLENE GLYCOL)
POLY(PROPYLENE GLYCOL)-B-POLY(ETHYLENE G LY-COL)-B-POLY(PROPYLENE GLYCOL) MN 330
POLY(PROPYLENE GLYCOL)-B-POLY(ETHYLENE G LY-COL)-B-POLY(PROPYLENE GLYCOL) MN 270
POLY(PROPYLENE GLYCOL)-B-POLY(ETHYLENE G LY-COL)-B-POLY(PROPYLENE GLYCOL) MN 200
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) average Mn ~1,100
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) average Mn ~1,900
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) average Mn ~2,000
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) average Mn ~2,800
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) average Mn ~2,900
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) average Mn ~4,400
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) average Mn ~5,800
Chemical Properties
| Melting point | 57-61 °C |
| Boiling point | >200 °C(lit.) |
| density | 1.095 g/mL at 25 °C |
| vapor density | >1 (vs air) |
| vapor pressure | <0.3 mm Hg ( 20 °C) |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: at <70 °Csoluble |
| form | solution |
| color | APHA: ≤120, 50/50 in CH3OH |
| PH | 5.0-7.5 (100g/L in H2O) |
| PH Range | 5.0 - 7.5 |
| Water Solubility | Miscible with water. |
| λmax | λ: 260 nm Amax: ≤0.3 λ: 280 nm Amax: ≤0..2 |
| Merck | 13,7644 |
| LogP | -1.293 (est) |
| Uses |
poloxamer 188 is a liquid surfactant polymer.
|
| EPA Substance Registry System | Oxirane, methyl-, polymer with oxirane(9003-11-6) |
Safety Data
| Hazard Codes | T |
| Risk Statements | |
| Safety Statements | |
| WGK Germany | 3 |
| RTECS | TP6164333 |
| TSCA | Yes |
| HS Code | 39059100 |
| Safety Profile |
When heated to
decomposition it emits acrid smoke and
irritating fumes.
|
| Hazardous Substances Data | 9003-11-6(Hazardous Substances Data) |
| Toxicity |
LD50 oral in rabbit: 35gm/kg
|
Raw materials And Preparation Products
Preparation Products
- finishing agent for polyester fiber
- polyurethane photosensitive prepolymer
- Polyurethane foam plastic
- Deinking agent for paper
- Yemianbao
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Hazard Information
Chemical Properties
93%
Usage
Hard and soft surface cleaners, defoamers in coatings and water treatment. Lubricant in metal working, anti-foaming aid and extender for linear and cross-linked polyesters and polyurethanes.
Usage
pyrethroid-based pesticide for use in mosquito control
Originator
Polykol ,Upjohn, US ,1958
Definition
ChEBI: Poloxamer is an epoxide.
Production Methods
Poloxamer polymers are prepared by reacting propylene oxide with
propylene glycol to form polyoxypropylene glycol. Ethylene oxide
is then added to form the block copolymer.
Manufacturing Process
(A) In a 1-liter 3-necked round bottom flask equipped with a mechanical stirrer, reflux condenser, thermometer and propylene oxide feed inlet, there were placed 57 g (0.75 mol) of propylene glycol and 7.5 g of anhydrous sodium hydroxide. The flask was purged with nitrogen to remove air and heated to 120°C with stirring and until the sodium hydroxide was dissolved. Then sufficient propylene oxide was introduced into the mixture as fast as it would react until the product possessed a calculated molecular weight of 2,380. The product was cooled under nitrogen, the NaOH catalyst neutralized with sulfuric acid and the product filtered. The final product was a waterinsoluble polyoxypropylene glycol having an average molecular weight of 1,620 as determined by hydroxyl number or acetylation analytical test procedures.
(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide. 105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A). The amount of added ethylene oxide corresponded to 17.4% of the total weight of the polyoxypropylene glycol base plus the weight of added ethylene oxide.
(B) The foregoing polyoxypropylene glycol having an average 1,620 molecular weight was placed in the same apparatus as described in procedure (A), in the amount of 500 g (0.308 mol), to which there was added 5 g of anhydrous sodium hydroxide. 105 g of ethylene oxide was added at an average temperature of 120°C, using the same technique as employed in (A). The amount of added ethylene oxide corresponded to 17.4% of the total weight of the polyoxypropylene glycol base plus the weight of added ethylene oxide.
Brand name
Lutrol F (BASF); Pluracare (BASF);
Pluronic (BASF).
Therapeutic Function
Pharmaceutic aid (surfactant)
General Description
Pluronic? L-81 is a lipoprotein secretion inhibitor.
Pharmaceutical Applications
Polyethylene-polypropylene glycol(9003-11-6) is nonionic polyoxyethylene–polyoxypropylene copolymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic. All of the Polyethylene-polypropylene glycol is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture. Their physical and surface-active properties vary over a wide range and a number of different types are commercially available;
Polyethylene-polypropylene glycol is used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups. Polyethylene-polypropylene glycol may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.
Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems. More recently,Polyethylene-polypropylene glycol has found use in drug-delivery systems.
Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as danthron. Polyethylene-polypropylene glycol may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.
Poloxamer 338 and 407 are used in solutions for contact lens care.
Polyethylene-polypropylene glycol is used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups. Polyethylene-polypropylene glycol may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.
Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems. More recently,Polyethylene-polypropylene glycol has found use in drug-delivery systems.
Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as danthron. Polyethylene-polypropylene glycol may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.
Poloxamer 338 and 407 are used in solutions for contact lens care.
Biological Activity
Polyethylene-polypropylene glycol(Poloxamer 188,9003-11-6) is a copolymer surfactant. Poloxamer 188 exhibits antithrombotic, anti-inflammatory and cytoprotective activities in various tissue injury models. It can be used to treat sickle cell disease in children and adults. It has also been shown to be protective against ischaemic injury, cardiomyopathy and cerebral haemorrhage.
Safety
Polyethylene-polypropylene glycol is used in a variety of oral, parenteral, and topical pharmaceutical formulations, and are generally regarded as nontoxic and nonirritant materials.Polyethylene-polypropylene glycol is not metabolized in the body.
Animal toxicity studies, with dogs and rabbits, have shown Polyethylene-polypropylene glycol to be nonirritating and nonsensitizing when applied in 5% w/v and 10% w/v concentration to the eyes, gums, and skin.
In a 14-day study of intravenous administration at concentrations up to 0.5 g/kg/day to rabbits, no overt adverse effects were noted. A similar study with dogs also showed no adverse effects at dosage levels up to 0.5 g/kg/day. In a longer-term study, rats fed 3% w/w or 5% w/w of poloxamer in food for up to 2 years did not exhibit any significant symptoms of toxicity. However, rats receiving 7.5% w/w of poloxamer in their diet showed some decrease in growth rate.
No hemolysis of human blood cells was observed over 18 hours at 25°C, with 0.001–10% w/v poloxamer solutions.
(mouse, IV): 1 g/kg
(mouse, oral): 15 g/kg
(mouse, SC): 5.5 g/kg
(rat, IV): 7.5 g/kg
(rat, oral): 9.4 g/kg
Animal toxicity studies, with dogs and rabbits, have shown Polyethylene-polypropylene glycol to be nonirritating and nonsensitizing when applied in 5% w/v and 10% w/v concentration to the eyes, gums, and skin.
In a 14-day study of intravenous administration at concentrations up to 0.5 g/kg/day to rabbits, no overt adverse effects were noted. A similar study with dogs also showed no adverse effects at dosage levels up to 0.5 g/kg/day. In a longer-term study, rats fed 3% w/w or 5% w/w of poloxamer in food for up to 2 years did not exhibit any significant symptoms of toxicity. However, rats receiving 7.5% w/w of poloxamer in their diet showed some decrease in growth rate.
No hemolysis of human blood cells was observed over 18 hours at 25°C, with 0.001–10% w/v poloxamer solutions.
(mouse, IV): 1 g/kg
(mouse, oral): 15 g/kg
(mouse, SC): 5.5 g/kg
(rat, IV): 7.5 g/kg
(rat, oral): 9.4 g/kg
storage
Polyethylene-polypropylene glycol is stable materials. Aqueous solutions are stable in the presence of acids, alkalis, and metal ions. However, aqueous solutions support mold growth.
The bulk material should be stored in a well-closed container in a cool, dry place.
The bulk material should be stored in a well-closed container in a cool, dry place.
Incompatibilities
Depending on the relative concentrations, poloxamer 188 is
incompatible with phenols and parabens.
Regulatory Status
Included in the FDA Inactive Ingredients Database (IV injections;
inhalations, ophthalmic preparations; oral powders, solutions,
suspensions, and syrups; topical preparations). Included in nonparenteral
medicines licensed in the UK. Included in the Canadian
List of Acceptable Non-medicinal Ingredients.
Supplier
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