ChemicalBook CAS DataBase List 6108-05-0

6108-05-0

Name	Linocaine hydrochloride
CAS	6108-05-0
EINECS(EC#)	200-803-8
Molecular Formula	C14H25ClN2O2
MDL Number	MFCD00150329
Molecular Weight	288.81
MOL File	6108-05-0.mol

Synonyms

ACETAMIDE,2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)-MONOHYDROCHLORIDE, MONOHYDRATE LIDOCAINE HCL HYDRATE LIDOCAINE HYDROCHLORIDE LIDOCAINE HYDROCHLORIDE, MONOHYDRATE LINOCAINE HYDROCHLORIDE 2’,6’-acetoxylidide,2-(diethylamino)-,hydrochloride,hydrate acetamide,2-(diethylamino)-n-(2,6-dimethylphenyl)-,monohydrochloride,monoh diethylaminoacet-2,6-xylididehydrochloridemonohydrate dolicaine lidocainemonohydratehydrochloride Lidocaine HCl USP LidocaineHclLidocaineHclBp 2-diethylamino-n-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate LIDOCAINEHYDROCHLORIDE,MONOHYDRATE,USP 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride LIDOCAINE HYDROCHLORIDE DAB, PH.EUR. LINOCAINE HCL Lignocaine monohydrate hydrochloride, Xylocaine monohydrate hydrochloride, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide monohydrate hydrochloride 2-Dimethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride

Chemical Properties

Appearance	White or almost white, crystalline powder.
Melting point	75-79℃
storage temp.	2-8°C
solubility	H₂O: soluble
form	solid
color	white
Water Solubility	Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.
InChI	InChI=1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
Contact allergens	Lidocaine is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic. less more
InChIKey	YECIFGHRMFEPJK-UHFFFAOYSA-N
SMILES	C1(C(C)=CC=CC=1C)NC(=O)CN(CC)CC.O.Cl
LogP	2.359 (est)
CAS DataBase Reference	6108-05-0(CAS DataBase Reference)

Safety Data

Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. less more
Safety Statements	S36:Wear suitable protective clothing . less more
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	AN7700000
TSCA	Yes
HazardClass	6.1
HS Code	2924296000

Hazard Information

Uses

A fast voltage-gated sodium channel blocker

Uses

Na+ channel blocker.

Uses

used in Local anesthesia and heart rhythm disorders.

Definition

ChEBI: The monohydrate form of lidocaine hydrochloride.

Chemical Properties

Linocaine hydrochloride is white or almost white, crystalline powder.

Application

Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.

Brand name

Alpha caine Hydrochloride (Carlisle); Anestacon (Polymedica); Laryng-O-Jet (International Medication); Lidocaton (Phar maton); Lidopen (Meridian); Xylocaine (Abraxis); Xylo caine (AstraZeneca); Xylocaine (Dentsply).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Mode of action

Lidocaine Hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.

Well-known Reagent Company Product Information

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