General Description
A crystalline solid. Denser than water and insoluble in water. Inhalation of dust or powder may cause adverse health reactions.
Reactivity Profile
A halogenated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
Air & Water Reactions
Insoluble in water.
Health Hazard
1,3-DICHLOROACETONE(534-07-6) may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution.
Potential Exposure
Formerly extensively used in textiles
(especially polyester fabrics) and still employed in polyurethane
foams, textile backcoating and adhesives.
Fire Hazard
When heated to decomposition, 1,3-DICHLOROACETONE emits highly toxic fumes of chlorides. This material may burn but does not ignite readily. Container may explode in heat of fire.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical
attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit. Keep
victim quiet and maintain normal body temperature. Effects
may be delayed; keep victim under observation.
Shipping
UN2649 1,3-Dichloroacetone, Hazard class: 6.1;
Labels: 6.1—Poisonous materials.
Chemical Properties
Bis(chhloromethyl)ketone is a crystalline solid.
Chemical Properties
White or colorless crystals
Uses
1,3-Dichloroacetone was used as acceptor substrate in the cross-aldol reaction with donor substrates such as acetone, cyclopentanone and cyclohexanon
Definition
ChEBI: 1,3-dichloroacetone is a ketone that is propan-2-one in which a hydrogen at positions 1 and 3 have been replaced by chloro groups. It is used in the synthesis of citric acid. Also used as a solvent and as an intermediate in organic synthesis. It is an organochlorine compound and a ketone. It is functionally related to a 1,3-dichloropropan-2-ol.
Safety Profile
Poison by inhalation. Mutationdata reported. A systemic irritant by ingestion andinhalation routes. Dangerous; whenheated to decomposition it emits highly toxic fumes ofCl-.
storage
Color Code—Blue: Health Hazard/Poison: Store in asecure poison location. Keep away from sources of ignition.Store in a refrigerator, in a tightly closed container. Storebelow 4℃. Keep away from oxidizers, heat, flame, and sparks.Shipping: The DOT label requirement for 1,3-Dichloroacetone is “POISONOUS/TOXIC MATERIALS.” TheHazard Class is 6.1 and the Packing Group is II.[19, 20]
Purification Methods
Crystallise it from CCl4, CHCl3 or *benzene and/or distil under vacuum [Conant & Quayle Org Synth Coll Vol I 211 1941, Hall & Sirel J Am Chem Soc 74 836 1952]. It is dimorphic [Daasch & Kagarise J Am Chem Soc 77 6156 1955]. The oxime has m 130-131o, b 106o/25mm [Arzneimittel-Forsch 8 638 1958]. [Beilstein 1 IV 3219.]
